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    Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform [ Mus musculus (house mouse) ]

    Gene ID: 19056, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppp3cbprovided by MGI
    Official Full Name
    protein phosphatase 3, catalytic subunit, beta isoformprovided by MGI
    Primary source
    MGI:MGI:107163
    See related
    Ensembl:ENSMUSG00000021816 AllianceGenome:MGI:107163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cnab; Calnb; CnAbeta; 1110063J16Rik
    Summary
    Enables calmodulin-dependent protein phosphatase activity. Involved in several processes, including positive regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of synaptic vesicle endocytosis; and skeletal muscle fiber development. Acts upstream of or within several processes, including circulatory system development; locomotion involved in locomotory behavior; and negative regulation of T cell mediated cytotoxicity. Located in T-tubule and Z disc. Is active in glutamatergic synapse. Is expressed in several structures, including brain; gastrocnemius muscle; genitourinary system; jaw skeleton; and tooth. Human ortholog(s) of this gene implicated in aortic valve stenosis. Orthologous to human PPP3CB (protein phosphatase 3 catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 36.0), frontal lobe adult (RPKM 32.9) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp3cb in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20549432..20596641, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20499364..20546573, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene annexin A7 Neighboring gene MSS51 mitochondrial translational activator Neighboring gene STARR-seq mESC enhancer starr_36112 Neighboring gene RIKEN cDNA 1810062O18 gene Neighboring gene ubiquitin specific peptidase 54 Neighboring gene STARR-positive B cell enhancer ABC_E11565 Neighboring gene myozenin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (6) 
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium-dependent protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin-dependent protein phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calmodulin-dependent protein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2B binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2B binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcineurin-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium-ion regulated exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lymphangiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of calcium ion import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of calcium ion import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lysosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lysosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to cytokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of calcineurin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of calcineurin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of calcineurin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein serine/threonine phosphatase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Names
    CAM-PRP catalytic subunit
    CNA beta
    PP2BA beta
    NP_001297355.1
    NP_001297356.1
    NP_032940.1
    XP_006518770.1
    XP_006518771.1
    XP_006518774.1
    XP_017171410.1
    XP_036014402.1
    XP_036014403.1
    XP_036014404.1
    XP_036014405.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310426.1NP_001297355.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is one amino acid shorter than isoform 1.
      Source sequence(s)
      AC146594, BC066000, BM219132, BQ175555, CJ112318
      Consensus CDS
      CCDS79266.1
      UniProtKB/TrEMBL
      E0CZ78, E9Q6P2
      Related
      ENSMUSP00000125630.2, ENSMUST00000161445.8
      Conserved Domains (1) summary
      cd07416
      Location:50354
      MPP_PP2B; PP2B, metallophosphatase domain
    2. NM_001310427.1NP_001297356.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
      Source sequence(s)
      AA120596, AC146594, BC066000, BM219132, BQ175555, CJ112318
      Consensus CDS
      CCDS79267.1
      UniProtKB/TrEMBL
      E9Q6P2, G3X8U7
      Related
      ENSMUSP00000022355.5, ENSMUST00000022355.11
      Conserved Domains (1) summary
      cd07416
      Location:50354
      MPP_PP2B; PP2B, metallophosphatase domain
    3. NM_008914.3NP_032940.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC146594, BC066000, BM219132, BQ175555, CJ112318
      Consensus CDS
      CCDS26846.1
      UniProtKB/Swiss-Prot
      P48453, Q6NZR4
      UniProtKB/TrEMBL
      E9Q6P2
      Related
      ENSMUSP00000125722.2, ENSMUST00000159027.8
      Conserved Domains (1) summary
      cd07416
      Location:50354
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20549432..20596641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518711.3XP_006518774.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

      UniProtKB/TrEMBL
      E9Q6P2
      Conserved Domains (1) summary
      cd07416
      Location:50354
      MPP_PP2B; PP2B, metallophosphatase domain
    2. XM_036158509.1XP_036014402.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2

      UniProtKB/TrEMBL
      E9Q6P2
      Conserved Domains (1) summary
      cd07416
      Location:50354
      MPP_PP2B; PP2B, metallophosphatase domain
    3. XM_006518708.3XP_006518771.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3

      UniProtKB/TrEMBL
      E9Q6P2
      Conserved Domains (1) summary
      cd07416
      Location:50354
      MPP_PP2B; PP2B, metallophosphatase domain
    4. XM_006518707.3XP_006518770.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A0A6B9EQU3, E9Q6P2
      Conserved Domains (1) summary
      cd07416
      Location:50354
      MPP_PP2B; PP2B, metallophosphatase domain
    5. XM_036158510.1XP_036014403.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X6

      Conserved Domains (1) summary
      cl13995
      Location:1167
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    6. XM_036158511.1XP_036014404.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7

      Conserved Domains (1) summary
      cl13995
      Location:1167
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    7. XM_017315921.3XP_017171410.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5

      Conserved Domains (1) summary
      cl13995
      Location:1167
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    8. XM_036158512.1XP_036014405.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8

      Conserved Domains (1) summary
      cl13995
      Location:1167
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain