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    CG7369 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7369provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037188
    Locus tag
    Dmel_CG7369
    See related
    AllianceGenome:FB:FBgn0037188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7369
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; ganglia; and pole plasm. Orthologous to several human genes including RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7369 in Genome Data Viewer
    Location:
    80A1-80A1; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22741793..22748614)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22734893..22741714)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45163 Neighboring gene uncharacterized protein Neighboring gene lethal (3) 04053 Neighboring gene long non-coding RNA:CR45961 Neighboring gene Secretory Pathway Calcium atpase Neighboring gene uncharacterized protein Neighboring gene jim

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. van Dam TJ, et al. Cell Signal, 2009 Nov. PMID 19567266
    2. Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Díez D, et al. Nucleic Acids Res, 2011 Jul. PMID 21447561, Free PMC Article
    3. The Landscape of the DNA Transposons in the Genome of the Horezu_LaPeri Strain of Drosophila melanogaster. Bologa AM, et al. Insects, 2023 May 25. PMID 37367310, Free PMC Article
    4. A functional genomic analysis of cell morphology using RNA interference. Kiger AA, et al. J Biol, 2003. PMID 14527345, Free PMC Article
    5. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7369-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22741793..22748614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141158.4 → NP_649415.2  uncharacterized protein Dmel_CG7369 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649415.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTU3, Q8SYL9
      Conserved Domains (2) summary
      smart00147
      Location:388 → 649
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:116 → 261
      RasGEF_N; RasGEF N-terminal motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTU3 Q7KTU3

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