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    Vinc Vinculin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31201, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vincprovided by FlyBase
    Official Full Name
    Vinculinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004397
    Locus tag
    Dmel_CG3299
    See related
    AllianceGenome:FB:FBgn0004397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3299; CT11081; Dmel\CG3299; Dmvincp; EG:103B4.1; Vin; Vin2EF; vinc; VINC
    Summary
    Predicted to enable alpha-catenin binding activity and beta-catenin binding activity. Predicted to be involved in cell adhesion. Located in cytoplasmic side of apical plasma membrane. Is expressed in several structures, including adult head; adult heart; gut section; larval muscle system; and spermatozoon. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Vinc in Genome Data Viewer
    Location:
    2E2-2E3; 1-0.8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2214347..2222567, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2108380..2116600, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Monocarboxylate transporter 1 Neighboring gene antisense RNA:CR43637 Neighboring gene Fatty acyl-CoA reductase in oenocytes Neighboring gene SET and MYND domain containing, arthropod-specific, member 8 Neighboring gene uncharacterized protein Neighboring gene pecanex Neighboring gene kurz

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cell-cell contact zone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    vinculin
    Names
    CG3299-PA
    CG3299-PB
    CG3299-PC
    Vinc-PA
    Vinc-PB
    Vinc-PC
    vinculin at 2EF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2214347..2222567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297884.1NP_001284813.1  vinculin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284813.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46037
      UniProtKB/TrEMBL
      Q24584, X2JAB9
      Conserved Domains (1) summary
      pfam01044
      Location:63960
      Vinculin; Vinculin family
    2. NM_057472.3NP_476820.1  vinculin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46037
      UniProtKB/TrEMBL
      Q24584, X2JAB9
      Related
      FBpp0070404
      Conserved Domains (1) summary
      pfam01044
      Location:63960
      Vinculin; Vinculin family
    3. NM_001297885.1NP_001284814.1  vinculin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284814.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46037
      UniProtKB/TrEMBL
      Q24584, X2JAB9
      Conserved Domains (1) summary
      pfam01044
      Location:63960
      Vinculin; Vinculin family