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    bol boule [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bolprovided by FlyBase
    Official Full Name
    bouleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011206
    Locus tag
    Dmel_CG4760
    See related
    AllianceGenome:FB:FBgn0011206
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT13332; Bol; BOL; Boule; CG4727; CG4760; Dmel\CG4760; lincRNA.485; ms(3)07272
    Summary
    Enables RNA binding activity. Involved in several processes, including G2/MI transition of meiotic cell cycle; regulation of female receptivity; and spermatocyte division. Located in cytoplasm; nucleus; and perikaryon. Is expressed in several structures, including Kenyon cell; adult brain cell body rind; adult head; brain; and male germline cell. Orthologous to human BOLL (boule homolog, RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bol in Genome Data Viewer
    Location:
    66F5-67A1; 3-28 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9097629..9134405, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9090729..9127505, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dihydropteridine reductase Neighboring gene Unconventional SNARE in the ER 1 Neighboring gene nervous wreck Neighboring gene mir-4940 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fruit(less) flies provide a clue. Burgoyne PS. Nature, 1996 Jun 27. PMID 8657275
    2. Nervous system function for the testis RNA-binding protein boule in Drosophila. Joiner ML, et al. J Neurogenet, 2004 Jan-Mar. PMID 15370196
    3. Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis. Williams PA, et al. Mol Biol Cell, 2016 Aug 1. PMID 27280388, Free PMC Article
    4. Widespread presence of human BOULE homologs among animals and conservation of their ancient reproductive function. Shah C, et al. PLoS Genet, 2010 Jul 15. PMID 20657660, Free PMC Article
    5. Spermatid cyst polarization in Drosophila depends upon apkc and the CPEB family translational regulator orb2. Xu S, et al. PLoS Genet, 2014 May. PMID 24830287, Free PMC Article

    See all (115) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This studt propose a novel function for Boule in the CNS as a negative regulator of developmental axon pruning.
      Title: Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning.
    2. regulatory interactions among Modulo, Boule, and the meiotic-arrest genes integrate meiosis and spermatid differentiation in the male germ line
      Title: Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c9134316-9130608 mobile_element_type = transposon:412{}962

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G2/MI transition of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatocyte division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    boule
    Names
    CG4760-PA
    CG4760-PB
    CG4760-PC
    CG4760-PD
    CG4760-PE
    CG4760-PF
    CG4760-PG
    CG4760-PH
    CG4760-PI
    bol-PA
    bol-PB
    bol-PC
    bol-PD
    bol-PE
    bol-PF
    bol-PG
    bol-PH
    bol-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9097629..9134405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274685.2 → NP_001261614.1  boule, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF25
      Conserved Domains (1) summary
      cd12412
      Location:31 → 111
      RRM_DAZL_BOULE; RNA recognition motif in AZoospermia (DAZ) autosomal homologs, DAZL (DAZ-like) and BOULE

    2. NM_001300063.1 → NP_001286992.1  boule, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286992.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24207, Q8T472, Q9VSU4, Q9VSU5
      UniProtKB/TrEMBL
      A4V1Q0
      Conserved Domains (1) summary
      cd12412
      Location:31 → 111
      RRM_DAZL_BOULE; RNA recognition motif in AZoospermia (DAZ) autosomal homologs, DAZL (DAZ-like) and BOULE

    3. NM_079265.4 → NP_523989.1  boule, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24207, Q8T472, Q9VSU4, Q9VSU5
      UniProtKB/TrEMBL
      A4V1Q0
      Related
      FBpp0076265
      Conserved Domains (1) summary
      cd12412
      Location:31 → 111
      RRM_DAZL_BOULE; RNA recognition motif in AZoospermia (DAZ) autosomal homologs, DAZL (DAZ-like) and BOULE

    4. NM_168318.3 → NP_729456.1  boule, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729456.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24207, Q8T472, Q9VSU4, Q9VSU5
      UniProtKB/TrEMBL
      A4V1Q0
      Related
      FBpp0076267
      Conserved Domains (1) summary
      cd12412
      Location:31 → 111
      RRM_DAZL_BOULE; RNA recognition motif in AZoospermia (DAZ) autosomal homologs, DAZL (DAZ-like) and BOULE

    5. NM_168320.2 → NP_729458.1  boule, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1Q1
      Related
      FBpp0076266
      Conserved Domains (2) summary
      TIGR01628
      Location:45 → 180
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12412
      Location:31 → 111
      RRM_DAZL_BOULE; RNA recognition motif (RRM) found in AZoospermia (DAZ) autosomal homologs, DAZL (DAZ-like) and BOULE

    6. NM_168319.2 → NP_729457.1  boule, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1Q1
      Related
      FBpp0076268
      Conserved Domains (2) summary
      TIGR01628
      Location:45 → 180
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12412
      Location:31 → 111
      RRM_DAZL_BOULE; RNA recognition motif (RRM) found in AZoospermia (DAZ) autosomal homologs, DAZL (DAZ-like) and BOULE

    7. NM_001169923.3 → NP_001163394.1  boule, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN06
      Conserved Domains (2) summary
      COG0724
      Location:32 → 88
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:31 → 94
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_001414140.1 → NP_001401036.1  boule, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0Y7

    9. NM_001414139.1 → NP_001401035.1  boule, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0Y6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V1Q0 A4V1Q0
    A4V1Q1 A4V1Q1
    M9PF25 M9PF25
    Q24207.1 Q24207
    Q6NN06 Q6NN06

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