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    Clp Clipper [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clpprovided by FlyBase
    Official Full Name
    Clipperprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015621
    Locus tag
    Dmel_CG3642
    See related
    AllianceGenome:FB:FBgn0015621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c6a; CG3642; clp; CLP; Cpsf30; CPSF30; Dmel\CG3642; Ssb-c6a
    Summary
    Enables RNA endonuclease activity. Predicted to be involved in mRNA processing. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in follicle cell; oocyte; organism; and ovary. Orthologous to several human genes including CPSF4 (cleavage and polyadenylation specific factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Clp in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (819964..821209)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (819964..821209)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Peroxin 12 Neighboring gene uncharacterized protein Neighboring gene Post-GPI attachment to proteins 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene dreadlocks

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA- and single-stranded DNA-binding (SSB) proteins expressed during Drosophila melanogaster oogenesis: a homolog of bacterial and eukaryotic mitochondrial SSBs. Stroumbakis ND, et al. Gene, 1994 Jun 10. PMID 8206370
    2. Cleavage of RNA hairpins mediated by a developmentally regulated CCCH zinc finger protein. Bai C, et al. Mol Cell Biol, 1996 Dec. PMID 8943320, Free PMC Article
    3. Drosophila clipper/CPSF 30K is a post-transcriptionally regulated nuclear protein that binds RNA containing GC clusters. Bai C, et al. Nucleic Acids Res, 1998 Apr 1. PMID 9512528, Free PMC Article
    4. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Sullivan KD, et al. Mol Cell, 2009 May 15. PMID 19450530, Free PMC Article
    5. Use of circular RNAs as markers of readthrough transcription to identify factors regulating cleavage/polyadenylation events. Liang D, et al. Methods, 2021 Dec. PMID 33882363, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    clipper
    Names
    CG3642-PA
    Clp-PA
    single stranded-binding protein c6a

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      819964..821209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057808.2 → NP_477156.1  clipper [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477156.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0JQ42, Q24081, Q9VPT8
      Related
      FBpp0077676, FBtr0078011
      Conserved Domains (2) summary
      smart00356
      Location:66 → 90
      ZnF_C3H1; zinc finger
      COG5084
      Location:12 → 175
      YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPT8.1 Q9VPT8

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