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    Trf2 TATA box binding protein-related factor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31773, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trf2provided by FlyBase
    Official Full Name
    TATA box binding protein-related factor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0261793
    Locus tag
    Dmel_CG18009
    See related
    AllianceGenome:FB:FBgn0261793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S
    Summary
    Enables several functions, including RNA polymerase II core promoter sequence-specific DNA binding activity; TFIIA-class transcription factor complex binding activity; and chromatin binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in several processes, including autophagic cell death; mRNA transcription by RNA polymerase II; and spiracle morphogenesis, open tracheal system. Located in chromosome and germ cell nucleus. Is expressed in several structures, including cyst cell of testis; germline cell; midline glial cell; midline primordium; and pole plasm. Orthologous to human TBPL1 (TATA-box binding protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Trf2 in Genome Data Viewer
    Location:
    7E7-7E9; 1-23 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8409272..8433011)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8303305..8327044)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class T Neighboring gene leg arista wing complex Neighboring gene uncharacterized protein Neighboring gene Mitoguardin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    TATA box binding protein-related factor 2
    Names
    CG18009-PE
    CG18009-PF
    CG18009-PG
    CG18009-PH
    CG18009-PI
    CG18009-PJ
    TATA box-binding protein related factor 2
    TBP related factor 2
    TBP-like factor
    TBP-related factor 2
    Trf2-PE
    Trf2-PF
    Trf2-PG
    Trf2-PH
    Trf2-PI
    Trf2-PJ
    lethal (1) G0039
    lethal (1) G0071
    lethal (1) G0295
    lethal (1) G0425

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8409272..8433011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206654.2NP_996377.1  TATA box binding protein-related factor 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T052, Q9W3F8, Q9W3F9, Q9XZD9
      Conserved Domains (2) summary
      PLN00062
      Location:202376
      PLN00062; TATA-box-binding protein; Provisional
      cd04517
      Location:200373
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
    2. NM_001169230.2NP_001162701.1  TATA box binding protein-related factor 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162701.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q07DP5
      Conserved Domains (4) summary
      PLN00062
      Location:12851459
      PLN00062; TATA-box-binding protein; Provisional
      cd04517
      Location:12831456
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
      cd16269
      Location:10371048
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:9671068
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. NM_001103435.3NP_001096905.1  TATA box binding protein-related factor 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q07DP5
      Conserved Domains (4) summary
      PLN00062
      Location:12851459
      PLN00062; TATA-box-binding protein; Provisional
      cd04517
      Location:12831456
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
      cd16269
      Location:10371048
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:9671068
      GBP_C; Guanylate-binding protein, C-terminal domain
    4. NM_001272400.1NP_001259329.1  TATA box binding protein-related factor 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259329.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHD8
      Conserved Domains (4) summary
      PLN00062
      Location:12841458
      PLN00062; TATA-box-binding protein; Provisional
      cd04517
      Location:12821455
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
      cd16269
      Location:10361047
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:9661067
      GBP_C; Guanylate-binding protein, C-terminal domain
    5. NM_078529.4NP_511084.2  TATA box binding protein-related factor 2, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511084.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T052, Q9W3F8, Q9W3F9, Q9XZD9
      Related
      FBpp0305945
      Conserved Domains (2) summary
      PLN00062
      Location:202376
      PLN00062; TATA-box-binding protein; Provisional
      cd04517
      Location:200373
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
    6. NM_001272401.1NP_001259330.1  TATA box binding protein-related factor 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q07DP5
      Conserved Domains (4) summary
      PLN00062
      Location:12851459
      PLN00062; TATA-box-binding protein; Provisional
      cd04517
      Location:12831456
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
      cd16269
      Location:10371048
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:9671068
      GBP_C; Guanylate-binding protein, C-terminal domain