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    CG6867 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32782, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6867provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030887
    Locus tag
    Dmel_CG6867
    See related
    AllianceGenome:FB:FBgn0030887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT21241; Dmel\CG6867
    Summary
    Involved in motor neuron axon guidance and synaptic target inhibition. Predicted to be active in extracellular space. Is expressed in muscle cell of A1-7 ventral longitudinal muscle 2 and muscle cell of ventral longitudinal muscle 1. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome; ocular hypertension; and open-angle glaucoma (multiple). Orthologous to several human genes including GLDN (gliomedin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6867 in Genome Data Viewer
    Location:
    16F5-16F5; 1-59 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18023870..18028261)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17917903..17922294)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Shaker Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dynein heavy chain at 16F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Wnt4 is a local repulsive cue that determines synaptic target specificity. Inaki M, et al. Curr Biol, 2007 Sep 18. PMID 17764943
    2. Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma. Carbone MA, et al. PLoS One, 2009. PMID 19148291, Free PMC Article
    3. Generation of neuromuscular specificity in Drosophila: novel mechanisms revealed by new technologies. Nose A. Front Mol Neurosci, 2012. PMID 22586369, Free PMC Article
    4. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Mukherjee C, et al. Cell Metab, 2020 Aug 4. PMID 32531201, Free PMC Article
    5. Comparative analysis of Hox downstream genes in Drosophila. Hueber SD, et al. Development, 2007 Jan. PMID 17166915

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic target inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6867-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18023870..18028261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133034.6 → NP_573262.2  uncharacterized protein Dmel_CG6867 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573262.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGN3, Q9VWZ7
      Related
      FBpp0088539
      Conserved Domains (5) summary
      cd00096
      Location:546 → 612
      Ig; Immunoglobulin domain
      pfam01391
      Location:306 → 364
      Collagen; Collagen triple helix repeat (20 copies)
      smart00408
      Location:449 → 511
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:442 → 525
      IG_like; Immunoglobulin like
      pfam02191
      Location:694 → 937
      OLF; Olfactomedin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGN3 Q8IGN3
    Q9VWZ7 Q9VWZ7

    Gene LinkOut

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