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    CG9961 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9961provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031451
    Locus tag
    Dmel_CG9961
    See related
    AllianceGenome:FB:FBgn0031451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9961
    Summary
    Predicted to enable ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Predicted to be involved in canonical glycolysis and gluconeogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9961 in Genome Data Viewer
    Location:
    23A3-23A3; 2-7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2743375..2744934, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2743375..2744934, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 1 Neighboring gene TBP-related factor 5 Neighboring gene uncharacterized protein Neighboring gene mir-4914 stem loop Neighboring gene Hepatocyte growth factor regulated tyrosine kinase substrate Neighboring gene Cwc25 Neighboring gene long non-coding RNA:CR44772 Neighboring gene Phosphoglycerate kinase Neighboring gene Bacchus

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression profiling of attenuated mitochondrial function identifies retrograde signals in Drosophila. Freije WA, et al. G3 (Bethesda), 2012 Aug. PMID 22908033, Free PMC Article
    2. A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function. Wang P, et al. J Neurosci, 2004 May 12. PMID 15140922, Free PMC Article
    3. PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development. Bamgbose G, et al. Life Sci Alliance, 2024 Feb. PMID 38012002, Free PMC Article
    4. Quantitative Proteomic Analyses of Molecular Mechanisms Associated with Cytoplasmic Incompatibility in Drosophila melanogaster Induced by Wolbachia. Yuan LL, et al. J Proteome Res, 2015 Sep 4. PMID 26220534
    5. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Huang Y, et al. PLoS Biol, 2013 Nov. PMID 24348200, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoglycerate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoglycerate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglycerate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9961-PA
    CG9961-PB
    NP_001259955.1
    NP_608704.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2743375..2744934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273026.1 → NP_001259955.1  uncharacterized protein Dmel_CG9961, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE85
      Conserved Domains (1) summary
      cl00198
      Location:37 → 86
      Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...

    2. NM_134860.3 → NP_608704.2  uncharacterized protein Dmel_CG9961, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608704.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T447, Q9VQF4
      Related
      FBpp0077420
      Conserved Domains (1) summary
      cl00198
      Location:36 → 447
      Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PE85 M9PE85
    Q8T447 Q8T447
    Q9VQF4 Q9VQF4

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