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    CG14020 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14020provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031707
    Locus tag
    Dmel_CG14020
    See related
    AllianceGenome:FB:FBgn0031707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14020
    Summary
    Predicted to be involved in cilium assembly and regulation of protein localization. Predicted to be active in ciliary membrane and ciliary transition zone. Human ortholog(s) of this gene implicated in Joubert syndrome 20 and Meckel syndrome. Orthologous to human TMEM231 (transmembrane protein 231). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14020 in Genome Data Viewer
    Location:
    25E5-25E5; 2-17 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5517737..5518949)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5517737..5518949)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene midline Neighboring gene long non-coding RNA:CR45287 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44793 Neighboring gene Vacuolar protein sorting 52 Neighboring gene clot Neighboring gene Elongator complex protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Basiri ML, et al. Curr Biol, 2014 Nov 17. PMID 25447994, Free PMC Article
    2. The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development. Miskolczi-McCallum CM, et al. Dev Biol, 2005 Feb 15. PMID 15680363
    3. Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. Kondylis V, et al. PLoS One, 2011 Feb 23. PMID 21383842, Free PMC Article
    4. Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. Halfon MS, et al. Genome Res, 2002 Jul. PMID 12097338, Free PMC Article
    5. Genomic regulatory blocks underlie extensive microsynteny conservation in insects. Engström PG, et al. Genome Res, 2007 Dec. PMID 17989259, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14020-PA
    CG14020-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5517737..5518949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135084.4 → NP_608928.1  uncharacterized protein Dmel_CG14020, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMR1
      Related
      FBpp0078727
      Conserved Domains (1) summary
      pfam10149
      Location:1 → 318
      TM231; Transmembrane protein 231

    2. NM_001273168.2 → NP_001260097.1  uncharacterized protein Dmel_CG14020, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB43
      Conserved Domains (1) summary
      pfam10149
      Location:1 → 318
      TM231; Transmembrane protein 231
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB43 M9PB43
    Q9VMR1 Q9VMR1

    Gene LinkOut

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