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    Pez Pez [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pezprovided by FlyBase
    Official Full Name
    Pezprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031799
    Locus tag
    Dmel_CG9493
    See related
    AllianceGenome:FB:FBgn0031799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9493; Dmel\CG9493; dPez; PEZ; PTPD1
    Summary
    Involved in several processes, including R8 cell differentiation; positive regulation of hippo signaling; and positive regulation of inflammatory response to wounding. Located in apical part of cell and cell cortex. Is active in lamellipodium. Orthologous to human PTPN14 (protein tyrosine phosphatase non-receptor type 14) and PTPN21 (protein tyrosine phosphatase non-receptor type 21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pez in Genome Data Viewer
    Location:
    26C3-26C3; 2-19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6332881..6338671, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6332881..6338671, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Discoidin domain receptor Neighboring gene uncharacterized protein Neighboring gene PDZ domain-containing guanine nucleotide exchange factor Neighboring gene Cytochrome P450 reductase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of the Band 4.1/ezrin-related protein tyrosine phosphatase Pez from two Drosophila species: implications for structure and function. Edwards K, et al. Gene, 2001 Sep 19. PMID 11587846
    2. The Hippo size control pathway--ever expanding. Lin JI, et al. Sci Signal, 2013 Jan 22. PMID 23354686
    3. Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Wang C, et al. Nat Commun, 2015 Mar 27. PMID 25814387
    4. PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo. Campbell JS, et al. Curr Biol, 2021 Feb 22. PMID 33296680, Free PMC Article
    5. PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation. Guo P, et al. Science, 2024 Aug 9. PMID 39116228

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables non-membrane spanning protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R8 cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in R8 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response to wounding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pez
    Names
    CG9493-PA
    CG9493-PB
    Pez-PA
    Pez-PB
    pez

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6332881..6338671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273198.1 → NP_001260127.1  Pez, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260127.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3V3
      Conserved Domains (6) summary
      smart00295
      Location:26 → 230
      B41; Band 4.1 homologues
      cd00047
      Location:1009 → 1243
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:225 → 317
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00102
      Location:1007 → 1243
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:114 → 230
      FERM_M; FERM central domain
      pfam09379
      Location:26 → 93
      FERM_N; FERM N-terminal domain

    2. NM_135169.3 → NP_609013.1  Pez, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609013.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3V3
      Related
      FBpp0078914
      Conserved Domains (6) summary
      smart00295
      Location:26 → 230
      B41; Band 4.1 homologues
      cd00047
      Location:1009 → 1243
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:225 → 317
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00102
      Location:1007 → 1243
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam00373
      Location:114 → 230
      FERM_M; FERM central domain
      pfam09379
      Location:26 → 93
      FERM_N; FERM N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3V3 Q9V3V3

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