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    Dpp10 Dipeptidyl peptidase 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33923, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dpp10provided by FlyBase
    Official Full Name
    Dipeptidyl peptidase 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0031835
    Locus tag
    Dmel_CG11319
    See related
    AllianceGenome:FB:FBgn0031835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11319; Dmel\CG11319; DPP10
    Summary
    Enables dipeptidyl-peptidase activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in proteolysis and regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of Kv4.3-DPP10 channel complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asthma; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to several human genes including DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Dpp10 in Genome Data Viewer
    Location:
    26E3-26F1; 2-21 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6568400..6601068, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6568400..6601068, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase subunit 5B-like Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene uncharacterized protein Neighboring gene Equilibrative nucleoside transporter 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44913 Neighboring gene Dpr-interacting protein iota

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in proteolysis  
    involved_in proteolysis PubMed 
    involved_in proteolysis  
    involved_in proteolysis PubMed 
    involved_in regulation of potassium ion transmembrane transport PubMed 
    Component Evidence Code Pubs
    part_of Kv4.3-DPP10 channel complex PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    part_of voltage-gated potassium channel complex PubMed 

    General protein information

    Preferred Names
    dipeptidyl peptidase 10
    Names
    CG11319-PA
    CG11319-PB
    CG11319-PC
    Dpp10-PA
    Dpp10-PB
    Dpp10-PC
    NP_001285682.1
    NP_001285683.1
    NP_609051.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6568400..6601068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135207.3 → NP_609051.1  dipeptidyl peptidase 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMB4
      Related
      FBpp0088584
      Conserved Domains (3) summary
      COG1506
      Location:641 → 916
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:711 → 916
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:123 → 504
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    2. NM_001298754.1 → NP_001285683.1  dipeptidyl peptidase 10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMB4
      Conserved Domains (3) summary
      COG1506
      Location:641 → 916
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:711 → 916
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:123 → 504
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    3. NM_001298753.1 → NP_001285682.1  dipeptidyl peptidase 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9P4
      Conserved Domains (3) summary
      COG1506
      Location:641 → 916
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:711 → 916
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:123 → 504
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
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