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    CG13398 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13398provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032042
    Locus tag
    Dmel_CG13398
    See related
    AllianceGenome:FB:FBgn0032042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG13398
    Summary
    Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in embryonic/larval midgut; organism; wing hinge primordium; and wing pouch. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2) and FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13398 in Genome Data Viewer
    Location:
    29C3-29C3; 2-32 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8412144..8415256, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8412144..8415256, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44991 Neighboring gene embargoed Neighboring gene N-acetyl-alpha-glucosaminidase Neighboring gene A kinase anchor protein 200 Neighboring gene gurken Neighboring gene D12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Akap200 suppresses the effects of Dv-cbl expression in the Drosophila eye. Sannang RT, et al. Mol Cell Biochem, 2012 Oct. PMID 22773306
    2. A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling. Trivedi D, et al. Elife, 2020 Dec 15. PMID 33320085, Free PMC Article
    3. Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Molnar C, et al. Genetics, 2012 Oct. PMID 22798488, Free PMC Article
    4. Phosphoinositide signalling in Drosophila. Balakrishnan SS, et al. Biochim Biophys Acta, 2015 Jun. PMID 25449646
    5. A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. Molnar C, et al. Genetics, 2006 Nov. PMID 16980395, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13398-PA
    CG13398-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8412144..8415256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273323.1 → NP_001260252.1  uncharacterized protein Dmel_CG13398, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT60, Q9VLL4
      Conserved Domains (1) summary
      cd01202
      Location:15 → 109
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

    2. NM_135383.2 → NP_609227.1  uncharacterized protein Dmel_CG13398, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT60, Q9VLL4
      Related
      FBpp0079315
      Conserved Domains (1) summary
      cd01202
      Location:15 → 109
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MT60 Q8MT60
    Q9VLL4 Q9VLL4

    Gene LinkOut

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