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    Mal-B1 Maltase B1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mal-B1provided by FlyBase
    Official Full Name
    Maltase B1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032381
    Locus tag
    Dmel_CG14934
    See related
    AllianceGenome:FB:FBgn0032381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14934; Dmel\CG14934; Drome_B1; mal_B1
    Summary
    Enables alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mal-B1 in Genome Data Viewer
    Location:
    33A3-33A4; 2-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11847226..11849169)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11847226..11849169)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphodiesterase 1c Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Maltase B2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AGI, a previously unreported D. melanogaster alpha-glucosidase: partial purification, characterization, and cytogenetic mapping. Parker GF, et al. Biochem Genet, 1996 Apr. PMID 8734412
    2. Comparative Transcriptomic Analysis Revealing the Potential Mechanisms of Erythritol-Caused Mortality and Oviposition Inhibition in Drosophila melanogaster. Li L, et al. Int J Mol Sci, 2024 Mar 27. PMID 38612549, Free PMC Article
    3. Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue. Erion R, et al. Elife, 2016 Apr 14. PMID 27077948, Free PMC Article
    4. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425
    5. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,4-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maltase B1
    Names
    CG14934-PA
    Mal-B1-PA
    NP_609522.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11847226..11849169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135678.2 → NP_609522.1  maltase B1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609522.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJ23, Q9VKE6
      Related
      FBpp0079859
      Conserved Domains (2) summary
      cd11328
      Location:30 → 500
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      TIGR02403
      Location:33 → 538
      trehalose_treC; alpha,alpha-phosphotrehalase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKE6 Q9VKE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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