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    Gpo2 Glycerophosphate oxidase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35689, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpo2provided by FlyBase
    Official Full Name
    Glycerophosphate oxidase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033190
    Locus tag
    Dmel_CG2137
    See related
    AllianceGenome:FB:FBgn0033190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    146747_at; alpha-GPO; CG2137; Dmel\CG2137; Gpo; GPO; gpo-2; GPO-2
    Summary
    Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol-3-phosphate metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gpo2 in Genome Data Viewer
    Location:
    43D3-43D3; 2-56 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7535919..7538297)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3423424..3425802)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Death resistor Adh domain containing target Neighboring gene long non-coding RNA:CR44209 Neighboring gene Cytochrome b5 Neighboring gene uncharacterized protein Neighboring gene corin Neighboring gene Ribulose-5-phosphate-3-epimerase Neighboring gene boca

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic and molecular analysis of the alpha glycerophosphate cycle in Drosophila melanogaster. MacIntyre RJ, et al. Isozymes Curr Top Biol Med Res, 1987. PMID 3110096
    2. The -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects. O'Brien SJ, et al. Biochem Genet, 1972 Oct. PMID 4340553
    3. Regulation of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster larvae by dietary ethanol and sucrose. Geer BW, et al. J Nutr, 1983 Aug. PMID 6410023
    4. The biological basis of ethanol tolerance in Drosophila. Geer BW, et al. Comp Biochem Physiol B, 1993 Jun. PMID 8359013
    5. Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. Emtenani S, et al. EMBO J, 2022 Jun 14. PMID 35319107, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol-3-phosphate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glycerophosphate oxidase 2
    Names
    CG2137-PA
    Gpo2-PA
    alpha glycerophosphate oxidase 2
    NP_610295.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7535919..7538297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136451.1 → NP_610295.1  glycerophosphate oxidase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z707, Q6AWE4
      Related
      FBpp0087981, FBtr0088907
      Conserved Domains (5) summary
      PLN02464
      Location:8 → 583
      PLN02464; glycerol-3-phosphate dehydrogenase
      pfam13499
      Location:614 → 671
      EF-hand_7; EF-hand domain pair
      pfam16901
      Location:443 → 569
      DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
      cl08302
      Location:614 → 672
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl21454
      Location:55 → 85
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z707 A1Z707

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