U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG1946 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35720, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG1946provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033216
    Locus tag
    Dmel_CG1946
    See related
    AllianceGenome:FB:FBgn0033216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1946
    Summary
    Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to several human genes including MOGAT2 (monoacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG1946 in Genome Data Viewer
    Location:
    43E12-43E12; 2-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7714923..7716781)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3602428..3604286)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mir-4909 stem loop Neighboring gene uncharacterized protein Neighboring gene Diacylglycerol O-acyltransferase 2 Neighboring gene Gdap2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila. Kühnlein RP. J Lipid Res, 2012 Aug. PMID 22566574, Free PMC Article
    2. Dietary Curcumin Intake and Its Effects on the Transcriptome and Metabolome of Drosophila melanogaster. Belcher S, et al. Int J Mol Sci, 2024 Jun 14. PMID 38928266, Free PMC Article
    3. A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown. Wat LW, et al. PLoS Biol, 2020 Jan. PMID 31961851, Free PMC Article
    4. Nuclear translocation ability of Lipin differentially affects gene expression and survival in fed and fasting Drosophila. Hood SE, et al. J Lipid Res, 2020 Dec. PMID 32989002, Free PMC Article
    5. Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster. Dembeck LM, et al. PLoS Genet, 2015 May. PMID 25933381, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacylglycerol O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG1946-PA
    NP_610319.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7714923..7716781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136475.4 → NP_610319.2  uncharacterized protein Dmel_CG1946 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610319.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z739
      Conserved Domains (1) summary
      cl17185
      Location:80 → 349
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z739 A1Z739

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous