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    Nop17l Nop17 like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nop17lprovided by FlyBase
    Official Full Name
    Nop17 likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033224
    Locus tag
    Dmel_CG1553
    See related
    AllianceGenome:FB:FBgn0033224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1553; Dmel\CG1553; nop17l
    Summary
    Enables protein phosphatase 1 binding activity. Predicted to be involved in axonemal dynein complex assembly. Predicted to be active in cytoplasm. Is expressed in chordotonal neurons and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 10. Orthologous to human DNAAF2 (dynein axonemal assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nop17l in Genome Data Viewer
    Location:
    43E17-43E18; 2-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7800785..7806385, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3688290..3693890, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glyceraldehyde 3 phosphate dehydrogenase 1 Neighboring gene DNA polymerase zeta subunit 1 Neighboring gene saxophone Neighboring gene Tubulin tyrosine ligase-like 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trafficking of siRNA precursors by the dsRBD protein Blanks in Drosophila. Nitschko V, et al. Nucleic Acids Res, 2020 Apr 17. PMID 32025726, Free PMC Article
    2. Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila. Bennett D, et al. J Mol Biol, 2006 Nov 24. PMID 17007873
    3. Drosophila melanogaster males respond differently at the behavioural and genome-wide levels to Drosophila melanogaster and Drosophila simulans females. Ellis LL, et al. J Evol Biol, 2009 Nov. PMID 19765174
    4. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nop17 like
    Names
    CG1553-PA
    CG1553-PB
    CG1553-PC
    NOP17 like
    Nop17l-PA
    Nop17l-PB
    Nop17l-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7800785..7806385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136480.3 → NP_610324.2  Nop17 like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610324.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C7LA99, E2QC75, Q0E9G3, Q8T8Q3
      Related
      FBpp0087974
      Conserved Domains (1) summary
      pfam08190
      Location:49 → 355
      PIH1; pre-RNA processing PIH1/Nop17

    2. NM_165557.2 → NP_724604.1  Nop17 like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C7LA99, E2QC75, Q0E9G3, Q8T8Q3
      Related
      FBpp0087976
      Conserved Domains (1) summary
      pfam08190
      Location:49 → 355
      PIH1; pre-RNA processing PIH1/Nop17

    3. NM_165558.2 → NP_724605.1  Nop17 like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C7LA99, E2QC75, Q0E9G3, Q8T8Q3
      Related
      FBpp0087975
      Conserved Domains (1) summary
      pfam08190
      Location:49 → 355
      PIH1; pre-RNA processing PIH1/Nop17
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E9G3.1 Q0E9G3

    Gene LinkOut

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