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    AIMP1 aaRS-interacting multifunctional protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35892, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIMP1provided by FlyBase
    Official Full Name
    aaRS-interacting multifunctional protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033351
    Locus tag
    Dmel_CG8235
    See related
    AllianceGenome:FB:FBgn0033351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8235; Dmel\CG8235
    Summary
    Predicted to enable tRNA binding activity. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including embryonic/larval midgut primordium; embryonic/larval salivary gland; foregut primordium; gut section; and hindgut proper primordium. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 3. Orthologous to human AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AIMP1 in Genome Data Viewer
    Location:
    44F8-44F8; 2-59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8927014..8928105, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4814519..4815610, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Poly(A)-binding protein-dependent poly(A) ribonuclease 2 Neighboring gene Baramicin B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Nayak P, et al. Front Cell Dev Biol, 2021. PMID 34660574, Free PMC Article
    2. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
    3. Transcriptional signature of an adult brain tumor in Drosophila. Loop T, et al. BMC Genomics, 2004 Apr 16. PMID 15090076, Free PMC Article
    4. Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Okada H, et al. Nat Commun, 2016 Sep 1. PMID 27582081, Free PMC Article
    5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aaRS-interacting multifunctional protein 1
    Names
    AIMP1-PA
    CG8235-PA
    aminoacyl-tRNA synthetase-interacting multifunctional protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8927014..8928105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136582.4 → NP_610426.2  aaRS-interacting multifunctional protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610426.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7K8
      Related
      FBpp0087757
      Conserved Domains (1) summary
      cd02799
      Location:161 → 262
      tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7K8 A1Z7K8
    Q8SYK9 Q8SYK9

    Gene LinkOut

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