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    Myoz1 myozenin 1 [ Mus musculus (house mouse) ]

    Gene ID: 59011, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myoz1provided by MGI
    Official Full Name
    myozenin 1provided by MGI
    Primary source
    MGI:MGI:1929471
    See related
    Ensembl:ENSMUSG00000068697 AllianceGenome:MGI:1929471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FATZ; Myoz; 2310001N11Rik
    Summary
    Enables protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including negative regulation of calcineurin-NFAT signaling cascade; negative regulation of skeletal muscle tissue regeneration; and sarcomere organization. Acts upstream of or within with a positive effect on skeletal muscle fiber adaptation. Located in actin cytoskeleton. Is expressed in diaphragm; heart; musculature; and tongue. Orthologous to human MYOZ1 (myozenin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 65.7) and lung adult (RPKM 3.9) See more
    Orthologs
    NEW
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    Genomic context

    See Myoz1 in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20699170..20706608, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20649102..20656540, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36112 Neighboring gene protein phosphatase 3, catalytic subunit, beta isoform Neighboring gene RIKEN cDNA 1810062O18 gene Neighboring gene ubiquitin specific peptidase 54 Neighboring gene STARR-positive B cell enhancer ABC_E11565 Neighboring gene STARR-positive B cell enhancer ABC_E7297 Neighboring gene synaptopodin 2-like Neighboring gene STARR-seq mESC enhancer starr_36115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21501696-21501849 Neighboring gene SEC24 homolog C, COPII coat complex component Neighboring gene microRNA 6946

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FATZ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables FATZ binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables FATZ binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actinin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular condensate scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine phosphatase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables telethonin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cytoskeleton IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in pseudopodium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myozenin-1
    Names
    calcineurin-2
    calsarcin-2
    filamin-, actinin- and telethonin-binding protein
    skeletal muscle-specific protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021508.3NP_067483.1  myozenin-1

      See identical proteins and their annotated locations for NP_067483.1

      Status: VALIDATED

      Source sequence(s)
      AK009077, AK041896, AV250577, BY790048
      Consensus CDS
      CCDS36819.1
      UniProtKB/Swiss-Prot
      Q8C9L3, Q9D7N4, Q9JK37
      Related
      ENSMUSP00000087955.7, ENSMUST00000090469.8
      Conserved Domains (1) summary
      pfam05556
      Location:1296
      Calsarcin; Calcineurin-binding protein (Calsarcin)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20699170..20706608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)