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    Doc2 Dorsocross2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39038, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Doc2provided by FlyBase
    Official Full Name
    Dorsocross2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035956
    Locus tag
    Dmel_CG5187
    See related
    AllianceGenome:FB:FBgn0035956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5187; Dm-DOC2; Dmel\CG5187; doc; Doc; Doc-2; doc2
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in anterior Malpighian tubule development; cardiocyte differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; epithelium; germ layer; head epidermis primordium; and visceral muscle primordium. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 5. Orthologous to human TBX6 (T-box transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Doc2 in Genome Data Viewer
    Location:
    66F1-66F1; 3-28 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9012686..9019246, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9005786..9012346, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dorsocross3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46451 Neighboring gene Dorsocross1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BAC clones generated from sheared DNA. Osoegawa K, et al. Genomics, 2007 Feb. PMID 17098394, Free PMC Article
    2. Multiple parameters shape the 3D chromatin structure of single nuclei at the doc locus in Drosophila. Götz M, et al. Nat Commun, 2022 Sep 14. PMID 36104317, Free PMC Article
    3. T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner. Fan Z, et al. Insect Biochem Mol Biol, 2021 Feb. PMID 33412239
    4. Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster. Wang J, et al. Mol Cell Biol, 2005 May. PMID 15870289, Free PMC Article
    5. Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development. Espinola SM, et al. Nat Genet, 2021 Apr. PMID 33795867

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner.
      Title: T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner.
    2. results suggest that Doc regulates the expression of Delta and influence the outcome of Notch signaling in the eye discs
      Title: Regulation of Notch signaling in the developing Drosophila eye by a T-box containing transcription factor, Dorsocross.
    3. Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc
      Title: The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc.
    4. Dorsocross genes are required for normal patterning of the dorsolateral ectoderm and, in particular, the repression of wingless and the ladybird homeobox genes within this area of the germ band
      Title: The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp.
    5. Required for the formation of all myocardial and pericardial cell types, with the exception of the Eve-positive pericardial cells.
      Title: The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior Malpighian tubule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cardiocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_positive_effect imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dorsocross2
    Names
    CG5187-PA
    Doc2-PA
    dorsocross

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9012686..9019246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140025.4 → NP_648282.1  Dorsocross2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648282.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VST2
      Related
      FBpp0076274
      Conserved Domains (1) summary
      cd00182
      Location:55 → 242
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VST2 Q9VST2

    Gene LinkOut

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