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    CG12289 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39279, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12289provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036160
    Locus tag
    Dmel_CG12289
    See related
    AllianceGenome:FB:FBgn0036160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT04143; Dmel\CG12289
    Summary
    Predicted to enable ketohexokinase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; response to hexose; and response to insulin. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12289 in Genome Data Viewer
    Location:
    68C9-68C9; 3-36 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11457076..11458470, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11450176..11451570, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44549 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fumarase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
    2. Identification of Drosophila Mutants Affecting Defense to an Entomopathogenic Fungus. Lu HL, et al. Sci Rep, 2015 Jul 23. PMID 26202798, Free PMC Article
    3. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ketohexokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ketohexokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ketohexokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to fructose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to glucose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to insulin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to sucrose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12289-PA
    NP_648465.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11457076..11458470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140208.2 → NP_648465.2  uncharacterized protein Dmel_CG12289 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648465.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLI4, Q9VTI3
      Related
      FBpp0075908
      Conserved Domains (1) summary
      cd01939
      Location:12 → 309
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTI3 Q9VTI3

    Gene LinkOut

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