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    SPoCk Secretory Pathway Calcium atpase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40495, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPoCkprovided by FlyBase
    Official Full Name
    Secretory Pathway Calcium atpaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052451
    Locus tag
    Dmel_CG32451
    See related
    AllianceGenome:FB:FBgn0052451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.249; ATP2C1/2; ATP2CD1; CG14449; CG32451; CG7651; Dmel\CG32451; sPoCk; SPoCK
    Summary
    Enables P-type calcium transporter activity. Involved in calcium ion transmembrane transport; intracellular calcium ion homeostasis; and peroxisomal membrane transport. Located in Golgi membrane; endoplasmic reticulum membrane; and peroxisomal membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Orthologous to several human genes including ATP2C1 (ATPase secretory pathway Ca2+ transporting 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SPoCk in Genome Data Viewer
    Location:
    80A1-80A2; 3-47 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22749444..22787631)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22742544..22780731)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45163 Neighboring gene lethal (3) 04053 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45961 Neighboring gene uncharacterized protein Neighboring gene jim Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acute lead (Pb(2+)) exposure increases calcium oxalate crystallization in the inner medullary collecting duct, and is ameliorated by Ca(2+)/Mg(2+)-ATPase inhibition, as well as Capa receptor and SPoCk C knockdown in a Drosophila melanogaster model of nephrolithiasis. Pando P, et al. Chem Biol Interact, 2024 Oct 1. PMID 39153536
    2. Genetic analyses uncover pleiotropic compensatory roles for Drosophila Nucleobindin-1 in inositol trisphosphate-mediated intracellular calcium homeostasis. Balasubramanian V, et al. Genome, 2020 Feb. PMID 31557446
    3. Diverse cell-specific patterns of alternative polyadenylation in Drosophila. Lee S, et al. Nat Commun, 2022 Sep 13. PMID 36100597, Free PMC Article
    4. Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Southall TD, et al. Physiol Genomics, 2006 Jun 16. PMID 16609144
    5. P-type ATPases in Caenorhabditis and Drosophila: implications for evolution of the P-type ATPase subunit families with special reference to the Na,K-ATPase and H,K-ATPase subgroup. Okamura H, et al. J Membr Biol, 2003 Jan 1. PMID 12532273

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 22756216-22756255 mobile_element_type = transposon:INE-1{}2612
    • Loc: 22759024-22759146 mobile_element_type = transposon:INE-1{}2613
    • Loc: 22761446-22766814 mobile_element_type = transposon:Ivk{}1098
    • Loc: 22780109-22780638 mobile_element_type = transposon:INE-1{}2615
    • Loc: 22786396-22786530 mobile_element_type = transposon:INE-1{}2617

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables P-type calcium transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables P-type manganese transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport from cytosol to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in manganese ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisomal membrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    secretory pathway calcium atpase
    Names
    CG32451-PA
    CG32451-PB
    CG32451-PC
    CG32451-PD
    CG32451-PE
    CG32451-PF
    CG32451-PG
    CG32451-PH
    SPoCk-PA
    SPoCk-PB
    SPoCk-PC
    SPoCk-PD
    SPoCk-PE
    SPoCk-PF
    SPoCk-PG
    SPoCk-PH
    NP_001097666.1
    NP_001163496.1
    NP_001246887.1
    NP_001262220.1
    NP_001356985.1
    NP_730742.1
    NP_730744.1
    NP_730745.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22749444..22787631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168961.5 → NP_730742.1  secretory pathway calcium atpase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58CL2, Q7KTU2
      Conserved Domains (6) summary
      TIGR01522
      Location:140 → 1021
      ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase
      COG4087
      Location:666 → 795
      COG4087; Soluble P-type ATPase [General function prediction only]
      pfam00122
      Location:221 → 455
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:844 → 1016
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:142 → 209
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:526 → 609
      Cation_ATPase; Cation transport ATPase (P-type)

    2. NM_001275291.1 → NP_001262220.1  secretory pathway calcium atpase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262220.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF5, M9PG15
      Conserved Domains (6) summary
      TIGR01522
      Location:110 → 1049
      ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase
      COG4087
      Location:760 → 823
      COG4087; Soluble P-type ATPase [General function prediction only]
      pfam00122
      Location:191 → 425
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:872 → 1044
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:112 → 179
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:496 → 579
      Cation_ATPase; Cation transport ATPase (P-type)

    3. NM_001104196.3 → NP_001097666.1  secretory pathway calcium atpase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNX2, D3PFF5
      Conserved Domains (6) summary
      TIGR01522
      Location:103 → 984
      ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase
      COG4087
      Location:629 → 758
      COG4087; Soluble P-type ATPase [General function prediction only]
      pfam00122
      Location:184 → 418
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:807 → 979
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:105 → 172
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:489 → 572
      Cation_ATPase; Cation transport ATPase (P-type)

    4. NM_001259958.2 → NP_001246887.1  secretory pathway calcium atpase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C5A0, D3PFF5
      Conserved Domains (1) summary
      cd02085
      Location:52 → 897
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p

    5. NM_168962.4 → NP_730744.1  secretory pathway calcium atpase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF5, Q8IPS6
      Related
      FBpp0078184
      Conserved Domains (1) summary
      cd02085
      Location:59 → 904
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p

    6. NM_001370004.1 → NP_001356985.1  secretory pathway calcium atpase, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K506, D3PFF5
      Conserved Domains (1) summary
      cd02085
      Location:36 → 881
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p

    7. NM_168963.4 → NP_730745.1  secretory pathway calcium atpase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF5, Q9VNR2
      Related
      FBpp0078183
      Conserved Domains (1) summary
      cd02085
      Location:36 → 881
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p

    8. NM_001170025.1 → NP_001163496.1  secretory pathway calcium atpase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163496.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C5A0, D3PFF5
      Conserved Domains (1) summary
      cd02085
      Location:52 → 897
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K506 A0A4D6K506
    A8JNX2 A8JNX2
    C1C5A0 C1C5A0
    M9PG15 M9PG15
    Q7KTU2 Q7KTU2
    Q8IPS6 Q8IPS6
    Q9VNR2 Q9VNR2

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