U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    m-cup mann-cup [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42076, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    m-cupprovided by FlyBase
    Official Full Name
    mann-cupprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038488
    Locus tag
    Dmel_CG11896
    See related
    AllianceGenome:FB:FBgn0038488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11896; Dmel\CG11896
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Is expressed in elongation stage spermatid; organism; and primary spermatocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See m-cup in Genome Data Viewer
    Location:
    89F1-89F1; 3-60 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17144475..17149412, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12970197..12975134, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene TweedleW Neighboring gene Deterin Neighboring gene Single-strand-selective monofunctional uracil-DNA glycosylase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila. Cammarata-Mouchtouris A, et al. PLoS Pathog, 2020 Apr. PMID 32339205, Free PMC Article
    2. Post-meiotic transcription in Drosophila testes. Barreau C, et al. Development, 2008 Jun. PMID 18434411
    3. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article
    4. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mann-cup
    Names
    CG11896-PA
    CG11896-PB
    m-cup-PA
    m-cup-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17144475..17149412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275731.1 → NP_001262660.1  mann-cup, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262660.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHA0, Q8T3S0
      Conserved Domains (4) summary
      cd00204
      Location:147 → 262
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:149 → 239
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:244 → 294
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:177 → 208
      ANK; ANK repeat [structural motif]

    2. NM_142350.2 → NP_650607.1  mann-cup, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3S0, Q9I7J2
      Related
      FBpp0082855
      Conserved Domains (4) summary
      cd00204
      Location:147 → 262
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:149 → 239
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:244 → 294
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:177 → 208
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHA0 A0A0B4KHA0
    Q8T3S0 Q8T3S0
    Q9I7J2 Q9I7J2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous