U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TwdlD TweedleD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43210, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TwdlDprovided by FlyBase
    Official Full Name
    TweedleDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039444
    Locus tag
    Dmel_CG14243
    See related
    AllianceGenome:FB:FBgn0039444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14243; Dmel\CG14243
    Summary
    A structural constituent of chitin-based larval cuticle. Involved in body morphogenesis and chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in dorsal head epidermis; embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TwdlD in Genome Data Viewer
    Location:
    97C3-97C3; 3-91 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26640025..26641054)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22465747..22466776)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46233 Neighboring gene TweedleS Neighboring gene beaten path VII Neighboring gene Tubby Neighboring gene TweedleQ

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tubby-RFP balancers for developmental analysis: FM7c 2xTb-RFP, CyO 2xTb-RFP, and TM3 2xTb-RFP. Pina C, et al. Genesis, 2012 Feb. PMID 21913310, Free PMC Article
    2. A corset function of exoskeletal ECM promotes body elongation in Drosophila. Tajiri R, et al. Commun Biol, 2021 Jan 19. PMID 33469125, Free PMC Article
    3. MOD(MDG4)-64.2 protein, isoform of MOD(MDG4) loci, directly interacts with the Tweedle protein family of Drosophila melanogaster. Golovnin AK, et al. Dokl Biochem Biophys, 2013 Sep. PMID 24150578
    4. Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila. Guan X, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075064, Free PMC Article
    5. The putative C-type lectin Schlaff ensures epidermal barrier compactness in Drosophila. Zuber R, et al. Sci Rep, 2019 Mar 29. PMID 30926832, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    TweedleD
    Names
    CG14243-PA
    TwdlD-PA
    tweedle

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26640025..26641054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143235.3 → NP_651492.1  TweedleD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYN9, Q9VBD2
      Related
      FBpp0084407
      Conserved Domains (1) summary
      smart00690
      Location:78 → 178
      DM5; Domain of unknown function, currently peculiar to Drosophila
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBD2 Q9VBD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools