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    CG5639 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5639provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039527
    Locus tag
    Dmel_CG5639
    See related
    AllianceGenome:FB:FBgn0039527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT17816; Dmel\CG5639
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell-matrix adhesion. Predicted to be located in extracellular region. Predicted to be active in basement membrane and extracellular space. Is expressed in adult fat body. Orthologous to several human genes including WFDC10A (WAP four-disulfide core domain 10A); WFDC10B (WAP four-disulfide core domain 10B); and WFDC11 (WAP four-disulfide core domain 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5639 in Genome Data Viewer
    Location:
    98A8-98A10; 3-94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27586474..27596130, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23412196..23421852, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene widerborst Neighboring gene partner of inscuteable Neighboring gene distracted Neighboring gene tusp Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development. Rice C, et al. Genetics, 2020 Dec. PMID 33115752, Free PMC Article
    2. Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Mathiyalagan N, et al. Genes (Basel), 2019 Oct 31. PMID 31683705, Free PMC Article
    3. Immunity-related genes and gene families in Anopheles gambiae. Christophides GK, et al. Science, 2002 Oct 4. PMID 12364793
    4. The circadian clock interacts with metabolic physiology to influence reproductive fitness. Xu K, et al. Cell Metab, 2011 Jun 8. PMID 21641546, Free PMC Article
    5. Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system. Egger B, et al. Development, 2002 Jul. PMID 12091301

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5639-PA
    N-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27586474..27596130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143313.2 → NP_651570.1  uncharacterized protein Dmel_CG5639 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MST1, Q9VB21
      Related
      FBpp0084572
      Conserved Domains (5) summary
      cd00191
      Location:38 → 101
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00095
      Location:784 → 830
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      pfam02822
      Location:911 → 936
      Antistasin; Antistasin family
      pfam14625
      Location:180 → 225
      Lustrin_cystein; Lustrin, cysteine-rich repeated domain
      cl00150
      Location:1090 → 1184
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MST1 Q8MST1
    Q9VB21 Q9VB21

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