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    CG12877 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43333, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12877provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039544
    Locus tag
    Dmel_CG12877
    See related
    AllianceGenome:FB:FBgn0039544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD30051; Dmel\CG12877; REXO1
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Predicted to be active in nucleus. Orthologous to several human genes including REXO1 (RNA exonuclease 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12877 in Genome Data Viewer
    Location:
    98B2-98B2; 3-94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27707100..27710857)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23532822..23536579)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene HSPB1 associated protein 1 Neighboring gene ALG-2 interacting protein X Neighboring gene barentsz Neighboring gene Carnitine O-octanoyltransferase Neighboring gene Ets at 98B Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 98a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole. van Eeden FJ, et al. J Cell Biol, 2001 Aug 6. PMID 11481346, Free PMC Article
    2. The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs. Gerstberger S, et al. Cell Rep, 2017 Oct 17. PMID 29045842, Free PMC Article
    3. The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Han BW, et al. Curr Biol, 2011 Nov 22. PMID 22055293, Free PMC Article
    4. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
    5. Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. Ringrose L, et al. Dev Cell, 2003 Nov. PMID 14602076

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12877-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27707100..27710857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038984.3 → NP_001034073.1  uncharacterized protein Dmel_CG12877 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034073.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDP6, Q5BIE2
      Conserved Domains (4) summary
      cd06145
      Location:834 → 983
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:847 → 991
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      pfam02724
      Location:129 → 199
      CDC45; CDC45-like protein
      pfam15870
      Location:572 → 736
      EloA-BP1; ElonginA binding-protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PDP6 Q2PDP6
    Q5BIE2 Q5BIE2
    Q8IH01 Q8IH01
    Q8IH09 Q8IH09

    Gene LinkOut

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