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    wat waterproof [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    watprovided by FlyBase
    Official Full Name
    waterproofprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039620
    Locus tag
    Dmel_CG1443
    See related
    AllianceGenome:FB:FBgn0039620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1443; Dmel\CG1443; FAR1; Wat
    Summary
    Enables alcohol-forming very long-chain fatty acyl-CoA reductase activity. Involved in long-chain fatty-acyl-CoA metabolic process. Located in apical part of cell and cytoplasm. Is expressed in adult head; embryonic/larval hindgut; and larval tracheal system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wat in Genome Data Viewer
    Location:
    98F5-98F5; 3-97 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28992977..29020406, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24818699..24846128, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Dpr-interacting protein gamma Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45669 Neighboring gene mir-4947 stem loop Neighboring gene long non-coding RNA:CR44264 Neighboring gene long non-coding RNA:CR45567

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation. Santoro C, et al. Sci Rep, 2022 Jul 29. PMID 35906462, Free PMC Article
    2. The fatty acyl-CoA reductase Waterproof mediates airway clearance in Drosophila. Jaspers MH, et al. Dev Biol, 2014 Jan 1. PMID 24183938
    3. Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. Casad ME, et al. Mol Genet Genomics, 2012 Apr. PMID 22398840, Free PMC Article
    4. Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila. Finet C, et al. Genome Biol Evol, 2019 Jun 1. PMID 31076758, Free PMC Article
    5. Advances in deciphering the genetic basis of insect cuticular hydrocarbon biosynthesis and variation. Holze H, et al. Heredity (Edinb), 2021 Feb. PMID 33139902, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    waterproof
    Names
    CG1443-PA
    wat-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28992977..29020406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143395.1 → NP_651652.2  waterproof [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651652.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MS59, Q9VAR3
      Related
      FBpp0084714, FBtr0085345
      Conserved Domains (3) summary
      cd09071
      Location:382 → 472
      FAR_C; C-terminal domain of fatty acyl CoA reductases
      cd05236
      Location:39 → 342
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      PLN02996
      Location:35 → 474
      PLN02996; fatty acyl-CoA reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS59.1 Q8MS59

    Gene LinkOut

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