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    CG4872 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32676, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4872provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030799
    Locus tag
    Dmel_CG4872
    See related
    AllianceGenome:FB:FBgn0030799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4872
    Summary
    Predicted to enable hormone binding activity; thiomorpholine-carboxylate dehydrogenase activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 40. Orthologous to human CRYM (crystallin mu). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4872 in Genome Data Viewer
    Location:
    15B4-15B4; 1-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16881347..16882790)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16775380..16776823)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Regulator of G-protein signaling 7 Neighboring gene uncharacterized protein Neighboring gene Nitrogen permease regulator-like 2 Neighboring gene RNA polymerase III subunit I Neighboring gene uncharacterized protein Neighboring gene Density regulated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article
    2. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article
    3. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    4. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
    5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiomorpholine-carboxylate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4872-PA
    NP_573173.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16881347..16882790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132945.3 → NP_573173.2  uncharacterized protein Dmel_CG4872 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573173.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY58, Q9VXA1
      Related
      FBpp0074113
      Conserved Domains (2) summary
      COG2423
      Location:8 → 344
      OCDMu; Ornithine cyclodeaminase/archaeal alanine dehydrogenase, mu-crystallin family [Amino acid transport and metabolism]
      cl21454
      Location:5 → 298
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SY58 Q8SY58

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