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    CG11811 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39213, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11811provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036099
    Locus tag
    Dmel_CG11811
    See related
    AllianceGenome:FB:FBgn0036099
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11811
    Summary
    Predicted to enable guanylate kinase activity. Predicted to be involved in purine nucleotide metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut; embryonic/larval midgut interstitial cell; and embryonic/larval midgut primordium. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11811 in Genome Data Viewer
    Location:
    67E6-67E7; 3-33 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10691024..10692598)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10684124..10685698)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Acireductone dioxygenase 1 Neighboring gene simjang Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 13 kDa B subunit Neighboring gene Ninjurin A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling. Chen AS, et al. Cancer Res, 2019 Mar 15. PMID 30530503, Free PMC Article
    2. From network analysis to experimental validation: identification of regulators of non-muscle myosin II contractility using the folded-gastrulation signaling pathway. Zhao A, et al. BMC Mol Cell Biol, 2023 Oct 11. PMID 37821823, Free PMC Article
    3. Unraveling the Genetic Basis for the Rapid Diversification of Male Genitalia between Drosophila Species. Hagen JFD, et al. Mol Biol Evol, 2021 Jan 23. PMID 32931587, Free PMC Article
    4. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
    5. SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis. Chaplot K, et al. Dis Model Mech, 2019 Feb 7. PMID 30635270, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in purine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11811-PA
    NP_648408.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10691024..10692598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140151.3 → NP_648408.1  uncharacterized protein Dmel_CG11811 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTB3
      Related
      FBpp0075994
      Conserved Domains (2) summary
      TIGR03263
      Location:36 → 216
      guanyl_kin; guanylate kinase
      pfam00625
      Location:34 → 219
      Guanylate_kin; Guanylate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTB3 Q9VTB3

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