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    jus julius seizure [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jusprovided by FlyBase
    Official Full Name
    julius seizureprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039647
    Locus tag
    Dmel_CG14509
    See related
    AllianceGenome:FB:FBgn0039647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14509; CG14510; Dmel\CG14509; Jus; sda
    Summary
    Involved in mechanosensory behavior and regulation of membrane potential. Is expressed in several structures, including adult cervical connective; adult head; ganglia; larval nervous system; and synaptic neuropil domain. Used to study epilepsy. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See jus in Genome Data Viewer
    Location:
    98F13-99A1; 3-97 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29171191..29194994, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24996913..25020716, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Regulatory particle non-ATPase 2 Neighboring gene red dog mine Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Metazoan SpoT homolog-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant. Marley R, et al. J Neurophysiol, 2011 Jul. PMID 21451059, Free PMC Article
    2. Extending julius seizure, a bang-sensitive gene, as a model for studying epileptogenesis: Cold shock, and a new insertional mutation. Dean D, et al. Fly (Austin), 2018 Jan 2. PMID 29125376, Free PMC Article
    3. Muscle degeneration in aging Drosophila flies: the role of mechanical stress. Chechenova M, et al. Skelet Muscle, 2024 Aug 20. PMID 39164781, Free PMC Article
    4. Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila. Kuebler D, et al. Brain Res, 2002 Dec 20. PMID 12468028
    5. Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants. Reynolds ER, et al. J Neurobiol, 2004 Mar. PMID 14978727

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. julius seizure (jus), formerly CG14509, which encodes a novel transmembrane domain protein, is responsible for seizure sensitivity.
      Title: julius seizure, a Drosophila Mutant, Defines a Neuronal Population Underlying Epileptogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    julius seizure
    Names
    CG14509-PB
    CG14509-PC
    CG14509-PD
    CG14509-PE
    jus-PB
    jus-PC
    jus-PD
    jus-PE
    slamdance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29171191..29194994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276130.1 → NP_001263059.1  julius seizure, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHA7
      Conserved Domains (1) summary
      pfam01683
      Location:231 → 272
      EB; EB module

    2. NM_001276131.1 → NP_001263060.1  julius seizure, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHT8
      Conserved Domains (1) summary
      pfam01683
      Location:231 → 272
      EB; EB module

    3. NM_001104492.2 → NP_001097962.1  julius seizure, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQS2
      Conserved Domains (1) summary
      pfam01683
      Location:231 → 272
      EB; EB module

    4. NM_001104493.2 → NP_001097963.1  julius seizure, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KC6
      Conserved Domains (1) summary
      pfam01683
      Location:231 → 272
      EB; EB module
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHA7 A0A0B4KHA7
    A0A0B4KHT8 A0A0B4KHT8
    Q32KC6 Q32KC6
    Q8MQS2 Q8MQS2

    Gene LinkOut

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