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    CG11912 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11912provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031248
    Locus tag
    Dmel_CG11912
    See related
    AllianceGenome:FB:FBgn0031248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.112; Dmel\CG11912; SP140
    Summary
    Enables serine hydrolase activity. Predicted to be involved in proteolysis. Orthologous to human CTRC (chymotrypsin C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11912 in Genome Data Viewer
    Location:
    21B8-21B8; 2-0.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (318362..319259, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (318362..319259, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Pi3K21B Neighboring gene long non-coding RNA:CR43719 Neighboring gene Phospholipase C at 21C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary changes in cis and trans gene regulation. Wittkopp PJ, et al. Nature, 2004 Jul 1. PMID 15229602
    2. Evolution of a cellular immune response in Drosophila: a phenotypic and genomic comparative analysis. Salazar-Jaramillo L, et al. Genome Biol Evol, 2014 Feb. PMID 24443439, Free PMC Article
    3. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
    4. A Drosophila screen identifies a role for histone methylation in ER stress preconditioning. Owings KG, et al. G3 (Bethesda), 2024 Feb 7. PMID 38098286, Free PMC Article
    5. Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. McGraw LA, et al. Curr Biol, 2004 Aug 24. PMID 15324670

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11912-PA
    NP_608517.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      318362..319259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134673.4 → NP_608517.1  uncharacterized protein Dmel_CG11912 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2S5, Q9VPN7
      Related
      FBpp0077758
      Conserved Domains (2) summary
      smart00020
      Location:29 → 264
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:30 → 267
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K2S5 Q7K2S5
    Q9VPN7 Q9VPN7

    Gene LinkOut

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