U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    shn schnurri [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36171, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    shnprovided by FlyBase
    Official Full Name
    schnurriprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003396
    Locus tag
    Dmel_CG7734
    See related
    AllianceGenome:FB:FBgn0003396
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:SD06302; CG7734; Dmel\CG7734; EP(2)2359; EP2359; l(2)04738; quo; Schnurri; SD06302; Shn; SHN
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coregulator activity. Involved in several processes, including digestive tract development; regulation of transcription by RNA polymerase II; and wing disc development. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; germ layer; gut section; and imaginal disc. Used to study juvenile polyposis syndrome. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 43. Orthologous to human HIVEP1 (HIVEP zinc finger 1); HIVEP2 (HIVEP zinc finger 2); and HIVEP3 (HIVEP zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See shn in Genome Data Viewer
    Location:
    47D5-47D7; 2-63 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11159086..11217394)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7046591..7104899)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Syntaxin 6 Neighboring gene uncharacterized protein Neighboring gene menage a trois

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic mapping of shn(E.3.2) in Drosophila melanogaster. Bieser K, et al. MicroPubl Biol, 2019 Jun 5. PMID 32550446, Free PMC Article
    2. Experimental assessment of the network properties of the Drosophila circadian clock. Beckwith EJ, et al. J Comp Neurol, 2015 Apr 15. PMID 25504089
    3. The brinker repressor system regulates injury-induced nociceptive sensitization in Drosophila melanogaster. McParland A, et al. Mol Pain, 2021 Jan-Dec. PMID 34399634, Free PMC Article
    4. punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline. Matunis E, et al. Development, 1997 Nov. PMID 9334286
    5. Schnurri interacts with Mad in a Dpp-dependent manner. Udagawa Y, et al. Genes Cells, 2000 May. PMID 10886364

    See all (248) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Medea and schnurri mRNAs encode transcriptional regulators required for activation and/or repression of Dpp target genes.
      Title: Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development.
    2. Shn-regulated paracrine signaling interaction between damaged retinal cells and hemocytes ensures recovery and homeostasis of the challenged tissue.
      Title: Schnurri regulates hemocyte function to promote tissue recovery after DNA damage.
    3. Shn of Drosophila engages in redundant and synergistic interactions with multiple corepressors.
      Title: The Drosophila Smad cofactor Schnurri engages in redundant and synergistic interactions with multiple corepressors.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of salivary gland boundary specification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc anterior/posterior pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription repressor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    schnurri
    Names
    CG7734-PA
    CG7734-PB
    CG7734-PC
    CG7734-PD
    CG7734-PE
    CG7734-PF
    quo vadis
    shn-PA
    shn-PB
    shn-PC
    shn-PD
    shn-PE
    shn-PF
    umnitza

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11159086..11217394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273953.1 → NP_001260882.1  schnurri, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260882.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9C5, Q24107
      Conserved Domains (5) summary
      sd00017
      Location:2263 → 2283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1773 → 1793
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1771 → 1793
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:2288 → 2314
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:1785 → 1810
      zf-H2C2_2; Zinc-finger double domain

    2. NM_206091.2 → NP_995813.1  schnurri, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8F4, Q24107
      Conserved Domains (5) summary
      sd00017
      Location:2308 → 2328
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1818 → 1838
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1816 → 1838
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:2333 → 2359
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:1830 → 1855
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001273954.1 → NP_001260883.1  schnurri, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFC0, Q24107
      Conserved Domains (5) summary
      sd00017
      Location:2308 → 2328
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1818 → 1838
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1816 → 1838
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:2333 → 2359
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:1830 → 1855
      zf-H2C2_2; Zinc-finger double domain

    4. NM_057375.4 → NP_476723.1  schnurri, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476723.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9C5, Q24107
      Related
      FBpp0087200
      Conserved Domains (5) summary
      sd00017
      Location:2263 → 2283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1773 → 1793
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1771 → 1793
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:2288 → 2314
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:1785 → 1810
      zf-H2C2_2; Zinc-finger double domain

    5. NM_134279.3 → NP_599106.1  schnurri, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599106.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9C5, Q24107
      Related
      FBpp0087201
      Conserved Domains (5) summary
      sd00017
      Location:2263 → 2283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1773 → 1793
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1771 → 1793
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:2288 → 2314
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:1785 → 1810
      zf-H2C2_2; Zinc-finger double domain

    6. NM_057376.3 → NP_476724.2  schnurri, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476724.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9C5, Q24107
      Related
      FBpp0087202
      Conserved Domains (5) summary
      sd00017
      Location:2263 → 2283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1773 → 1793
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1771 → 1793
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:2288 → 2314
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:1785 → 1810
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFC0 A0A0B4KFC0
    A1Z8F4 A1Z8F4
    Q0E9C5 Q0E9C5
    Q24107 Q24107
    Q24605 Q24605
    Q8MQL7 Q8MQL7
    Q8SZT5 Q8SZT5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools