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    TyrRS-m Tyrosyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TyrRS-mprovided by FlyBase
    Official Full Name
    Tyrosyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035064
    Locus tag
    Dmel_CG16912
    See related
    AllianceGenome:FB:FBgn0035064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aatm; Aats-try-m; Aats-tyr-m; anon-EST:fe1E12; CG16912; Dmel\CG16912
    Summary
    Predicted to enable tyrosine-tRNA ligase activity. Predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TyrRS-m in Genome Data Viewer
    Location:
    60E1-60E1; 2-107 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24781726..24783500, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20669249..20671023, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44067 Neighboring gene eggless Neighboring gene Larval cuticle protein 9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene kenny Neighboring gene Rhythmically expressed gene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments. Rand DM, et al. Philos Trans R Soc Lond B Biol Sci, 2020 Jan 20. PMID 31787039, Free PMC Article
    2. Incompatibility between mitochondrial and nuclear genomes during oogenesis results in ovarian failure and embryonic lethality. Zhang C, et al. Development, 2017 Jul 1. PMID 28576772, Free PMC Article
    3. An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises development and fitness in Drosophila. Meiklejohn CD, et al. PLoS Genet, 2013. PMID 23382693, Free PMC Article
    4. Pleiotropic effects of a mitochondrial-nuclear incompatibility depend upon the accelerating effect of temperature in Drosophila. Hoekstra LA, et al. Genetics, 2013 Nov. PMID 24026098, Free PMC Article
    5. A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase. Holmbeck MA, et al. Dis Model Mech, 2015 Aug 1. PMID 26035388, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tyrosine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tyrosine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tyrosine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial tyrosyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tyrosyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tyrosyl-tRNA synthetase, mitochondrial
    Names
    CG16912-PA
    TyrRS-m-PA
    anon-fast-evolving-1E12
    mitochondrial tyrosyl-tRNA synthetase
    NP_611967.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24781726..24783500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138123.3 → NP_611967.1  Tyrosyl-tRNA synthetase, mitochondrial [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6L8, Q8MZ26, Q95S33, Q9W107
      Related
      FBpp0072334
      Conserved Domains (2) summary
      cd00805
      Location:58 → 345
      TyrRS_core; catalytic core domain of tyrosinyl-tRNA synthetase
      PRK05912
      Location:23 → 463
      PRK05912; tyrosyl-tRNA synthetase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W107.1 Q9W107

    Gene LinkOut

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