spoon spoonbill [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: spoonprovided by FlyBase
Official Full Name: spoonbillprovided by FlyBase
Primary source: FLYBASE:FBgn0263987
Locus tag: Dmel_CG3249
See related: AllianceGenome:FB:FBgn0263987
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AKAP Yu; BcDNA:GM04319; CG3249; Dmel\CG3249; mdi; PKAAP; Spoon; yu; Yu
Summary: Enables JUN kinase binding activity and mitochondrion-plasma membrane adaptor activity. Involved in several processes, including dorsal appendage formation; follicle cell of egg chamber development; and positive regulation of signal transduction. Is active in mitochondrial outer membrane. Colocalizes with Golgi apparatus. Is expressed in several structures, including adult head; adult mushroom body; anterior endoderm; embryonic/larval midgut primordium; and larval somatic muscle cell. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 4F9-4F10; 1-11 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5412386..5420867, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5306419..5314900, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spoonbill positively regulates JNK signalling mediated apoptosis in Drosophila melanogaster.
Title: Spoonbill positively regulates JNK signalling mediated apoptosis in Drosophila melanogaster.
We report suppression of SCA8 associated neurodegeneration by KH RNA binding domain of Spoonbill. KH domain suppresses pathogenic SCA8 associated phenotype. Ectopic expression of KH domain leads to massive reduction in the number and size of SCA8 RNA foci. We show that Spoonbill interacts with toxic SCA8 transcripts via its KH domain and promotes its depletion.
Title: The RNA binding KH domain of Spoonbill depletes pathogenic non-coding spinocerebellar ataxia 8 transcripts and suppresses neurodegeneration in Drosophila.
Spoon is a novel interacting partner of Prospero and this might be critical in determining the polarized localization of cell fate determinants.
Title: Interaction of Spoonbill with Prospero in Drosophila: Implications in neuroblast development.
proper localization of cAMP-protein kinase A by Yu A-kinase anchoring protein in mushroom body neurons is required for the formation of long-term memory.
Title: The AKAP Yu is required for olfactory long-term memory formation in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1895 (e-PCR)
- UniSTS:24221

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables JUN kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mitochondrion-plasma membrane adaptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centripetally migrating follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament polymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: spoonbill

Names: AKAP Yu; CG3249-PA; CG3249-PC; CG3249-PD; CG3249-PE; PKA anchor protein; mitochondrial DNA insufficient; spoon-PA; spoon-PC; spoon-PD; spoon-PE; yu

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5412386..5420867 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167034.2 → NP_726992.2 spoonbill, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726992.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KVW1

Related

FBpp0070761

Conserved Domains (3) summary

cd00105
Location:311 → 373

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:413 → 536

TUDOR; Tudor domain

cl02573
Location:465 → 522

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
NM_131993.4 → NP_572221.1 spoonbill, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572221.1

Status: REVIEWED

UniProtKB/TrEMBL

Q961E4, Q9W4C4

Related

FBpp0070760

Conserved Domains (3) summary

cd00105
Location:289 → 351

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:391 → 514

TUDOR; Tudor domain

cl02573
Location:443 → 500

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
NM_167033.3 → NP_726991.1 spoonbill, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726991.1

Status: REVIEWED

UniProtKB/TrEMBL

Q961E4, Q9W4C4

Related

FBpp0300894

Conserved Domains (3) summary

cd00105
Location:289 → 351

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:391 → 514

TUDOR; Tudor domain

cl02573
Location:443 → 500

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
NM_001258603.2 → NP_001245532.1 spoonbill, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245532.1

Status: REVIEWED

UniProtKB/TrEMBL

Q961E4, Q9W4C4

Conserved Domains (3) summary

cd00105
Location:289 → 351

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00567
Location:391 → 514

TUDOR; Tudor domain

cl02573
Location:443 → 500

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...