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    fat-spondin fat-spondin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fat-spondinprovided by FlyBase
    Official Full Name
    fat-spondinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026721
    Locus tag
    Dmel_CG6953
    See related
    AllianceGenome:FB:FBgn0026721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6953; CT21501; Dmel\CG6953; Dmel_CG6953; Fat-spondin
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell adhesion. Located in extracellular region. Is expressed in embryonic/larval fat body; embryonic/larval plasmatocyte; fat body/gonad primordium; plasmatocyte primordium; and yolk nucleus. Orthologous to human SPON1 (spondin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fat-spondin in Genome Data Viewer
    Location:
    53F2-53F3; 2-81 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17054002..17059299)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12941507..12946804)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, arthropod-specific, member 6 Neighboring gene uncharacterized protein Neighboring gene teflon Neighboring gene uncharacterized protein Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila. Nechaev S, et al. Science, 2010 Jan 15. PMID 20007866, Free PMC Article
    2. Comparative analysis of Drosophila melanogaster and Caenorhabditis elegans gene expression experiments in the European Soyuz flights to the International Space Station. Leandro LJ, et al. Adv Space Res, 2007 Apr. PMID 18084631, Free PMC Article
    3. Molecular characterization of teflon, a gene required for meiotic autosome segregation in male Drosophila melanogaster. Arya GH, et al. Genetics, 2006 Sep. PMID 16816414, Free PMC Article
    4. Tango1 spatially organizes ER exit sites to control ER export. Liu M, et al. J Cell Biol, 2017 Apr 3. PMID 28280122, Free PMC Article
    5. Evidence that human genes of modular proteins have retained significantly more ancestral introns than their fly or worm orthologues. Bányai L, et al. FEBS Lett, 2004 May 7. PMID 15135065

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    fat-spondin
    Names
    CG6953-PA
    fat-spondin-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17054002..17059299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058087.5 → NP_477435.1  fat-spondin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN04
      Related
      FBpp0086129
      Conserved Domains (4) summary
      smart00209
      Location:714 → 763
      TSP1; Thrombospondin type 1 repeats
      cd08544
      Location:24 → 172
      Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam00014
      Location:643 → 694
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam06468
      Location:191 → 378
      Spond_N; Spondin_N
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KN04 Q7KN04
    Q95S22 Q95S22

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