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    RAF2 RING-associated factor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RAF2provided by FlyBase
    Official Full Name
    RING-associated factor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036624
    Locus tag
    Dmel_CG4877
    See related
    AllianceGenome:FB:FBgn0036624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4689; CG4877; Dmel\CG4877; dRAF2; Raf2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of PcG protein complex. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RAF2 in Genome Data Viewer
    Location:
    72E4-72E4; 3-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16386327..16390816)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16379427..16383916)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 3 Neighboring gene uncharacterized protein Neighboring gene Gag-related Neighboring gene failed axon connections

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila. Zhang Y, et al. Mol Biol Rep, 2013 Sep. PMID 23681549
    2. Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila. Raich N, et al. Open Biol, 2018 Oct 17. PMID 30333236, Free PMC Article
    3. dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Lagarou A, et al. Genes Dev, 2008 Oct 15. PMID 18923078, Free PMC Article
    4. DEAF-1 function is essential for the early embryonic development of Drosophila. Veraksa A, et al. Genesis, 2002 Jun. PMID 12112874
    5. The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster. Jin W, et al. Nat Genet, 2001 Dec. PMID 11726925

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING-associated factor 2
    Names
    CG4877-PA
    CG4877-PB
    CG4877-PC
    RAF2-PA
    RAF2-PB
    RAF2-PC
    dRING-associated factor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16386327..16390816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168664.2 → NP_730163.1  RING-associated factor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RV6, Q9VV52
      Related
      FBpp0075145
      Conserved Domains (1) summary
      pfam01753
      Location:1078 → 1115
      zf-MYND; MYND finger

    2. NM_001275014.1 → NP_001261943.1  RING-associated factor 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261943.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RV6, Q9VV52
      Conserved Domains (1) summary
      pfam01753
      Location:1078 → 1115
      zf-MYND; MYND finger

    3. NM_140632.3 → NP_648889.2  RING-associated factor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648889.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RV6, Q9VV52
      Related
      FBpp0075144
      Conserved Domains (1) summary
      pfam01753
      Location:1078 → 1115
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VV52 Q9VV52

    Gene LinkOut

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