Scsalpha1 Succinyl-coenzyme A synthetase alpha subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Scsalpha1provided by FlyBase
Official Full Name: Succinyl-coenzyme A synthetase alpha subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0004888
Locus tag: Dmel_CG1065
See related: AllianceGenome:FB:FBgn0004888
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1065; Dmel\CG1065; Scs-alpha; Scsa; scsalpha; Scsalpha
Summary: Enables succinate-CoA ligase activity. Involved in tricarboxylic acid cycle. Located in mitochondrion. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 63F1-63F1; 3-9 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3814211..3818383)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3814211..3818383)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila SCS deficiency, designated Scsalpha(KO), contained a high level of succinyl-CoA, a substrate for the enzyme, and altered levels of various metabolites in TCA cycle and glycolysis, indicating that the energy metabolism was impaired
Title: Deficiency of succinyl-CoA synthetase α subunit delays development, impairs locomotor activity and reduces survival under starvation in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables succinate-CoA ligase (ADP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (GDP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of succinate-CoA ligase complex (ADP-forming)	IBA Inferred from Biological aspect of Ancestor more info
part_of succinate-CoA ligase complex (GDP-forming)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Succinyl-coenzyme A synthetase alpha subunit 1

Names: CG1065-PA; CG1065-PB; Scsalpha1-PA; Scsalpha1-PB; succinyl CoA synthetase; succinyl coenzyme A synthatase, alpha subunit; succinyl coenzyme A synthetase alpha subunit; succinyl-CoA synthetase alpha-subunit

NP_001189044.1

EC 6.2.1.4

EC 6.2.1.5

NP_523905.2

EC 6.2.1.4

EC 6.2.1.5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

3814211..3818383

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079181.4 → NP_523905.2 Succinyl-coenzyme A synthetase alpha subunit 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523905.2

Status: REVIEWED

UniProtKB/Swiss-Prot

M9MRQ9, Q8SXM7, Q94522, Q9VZM4

Related

FBpp0073010

Conserved Domains (1) summary

PTZ00187
Location:22 → 325

PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
NM_001202115.2 → NP_001189044.1 Succinyl-coenzyme A synthetase alpha subunit 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189044.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9MRQ9, Q8SXM7, Q94522, Q9VZM4

Conserved Domains (1) summary

PTZ00187
Location:22 → 325

PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional