Saf6 SAGA factor-like TAF6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Saf6provided by FlyBase
Official Full Name: SAGA factor-like TAF6provided by FlyBase
Primary source: FLYBASE:FBgn0031281
Locus tag: Dmel_CG3883
See related: AllianceGenome:FB:FBgn0031281
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3883; Dmel\CG3883; dSaf6; saf6; SAF6
Summary: Enables protein heterodimerization activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of SAGA complex. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (813314..815950, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (813314..815950, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

SAF6 (SAGA factor-like TAF6) is essential for SAGA coactivator function independent of the enzymatic activities of the complex
Title: A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IEA Inferred from Electronic Annotation more info
part_of SAGA-type complex	IDA Inferred from Direct Assay more info	PubMed
part_of SLIK (SAGA-like) complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	IEA Inferred from Electronic Annotation more info