TAF1B TATA box-binding protein-associated factor RNA polymerase I subunit B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TAF1Bprovided by FlyBase
Official Full Name: TATA box-binding protein-associated factor RNA polymerase I subunit Bprovided by FlyBase
Primary source: FLYBASE:FBgn0037792
Locus tag: Dmel_CG6241
See related: AllianceGenome:FB:FBgn0037792
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6241; Dmel\CG6241; Taf1B; TAF1b
Summary: Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus. Part of RNA polymerase transcription factor SL1 complex. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to human TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10140103..10144184, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5965825..5969906, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA polymerase I core promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I core promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase I core promoter sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA polymerase I preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase I preinitiation complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleolar large rRNA transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleolar large rRNA transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase I	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase I core factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase I core factor complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase transcription factor SL1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase transcription factor SL1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed

Preferred Names: TATA box-binding protein-associated factor RNA polymerase I subunit B

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The following sections contain reference sequences that belong to a specific genome build. Explain