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    DUBAI Deubiquitinating apoptotic inhibitor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36361, updated on 17-Dec-2024

    Summary

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    Official Symbol
    DUBAIprovided by FlyBase
    Official Full Name
    Deubiquitinating apoptotic inhibitorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033738
    Locus tag
    Dmel_CG8830
    See related
    AllianceGenome:FB:FBgn0033738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8830; Dmel\CG8830; Q7JQI1; Usp38
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in negative regulation of apoptotic process and negative regulation of proteolysis involved in protein catabolic process. Predicted to be active in cytosol and nucleus. Is expressed in spermatozoon. Orthologous to human USP35 (ubiquitin specific peptidase 35) and USP38 (ubiquitin specific peptidase 38). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DUBAI in Genome Data Viewer
    Location:
    49A4-49A6; 2-67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12431447..12436577, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8318952..8324082, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Deoxyribose-phosphate aldolase Neighboring gene Nucleoporin 54kD Neighboring gene uncharacterized protein Neighboring gene Transmembrane protein 18 Neighboring gene Dystrobrevin Neighboring gene uncharacterized protein Neighboring gene Lachesin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of survivin protein stability by USP35 is evolutionarily conserved. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 15. PMID 34438346
    2. The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling. Wiemerslage L, et al. J Endocrinol, 2016 Jun. PMID 27029472
    3. Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster. Zhang W, et al. BMC Bioinformatics, 2008 Feb 28. PMID 18307794, Free PMC Article
    4. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Chen X, et al. Genetics, 2000 Dec. PMID 11102377, Free PMC Article
    5. The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. Yang CS, et al. Cell Death Differ, 2014 Apr. PMID 24362437, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis involved in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    deubiquitinating apoptotic inhibitor
    Names
    CG8830-PA
    CG8830-PB
    DUBAI-PA
    DUBAI-PB
    DeUBiquitinating-Apoptotic-Inhibitor
    NP_610784.1
    NP_725167.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12431447..12436577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165900.2 → NP_725167.1  deubiquitinating apoptotic inhibitor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQI1
      Related
      FBpp0087061
      Conserved Domains (2) summary
      cd02664
      Location:359 → 739
      Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:358 → 738
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_136940.2 → NP_610784.1  deubiquitinating apoptotic inhibitor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQI1
      Related
      FBpp0087062
      Conserved Domains (2) summary
      cd02664
      Location:359 → 739
      Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:358 → 738
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQI1 Q7JQI1

    Gene LinkOut

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