Mondo mondo [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mondoprovided by FlyBase
Official Full Name: mondoprovided by FlyBase
Primary source: FLYBASE:FBgn0032940
Locus tag: Dmel_CG18362
See related: AllianceGenome:FB:FBgn0032940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 154826_at; anon-39Da; bHLHd12; CG18362; ChREBP; Dmel\CG18362; dmondo; mio; Mio; mlx; mondo; Mondo-Mlx
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Predicted to contribute to DNA binding activity. Involved in glucose homeostasis; response to sucrose; and triglyceride homeostasis. Located in cytosol. Is expressed in several structures, including adult brain; amnioserosa; anterior endoderm anlage; ganglia; and mesoderm. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human MLXIP (MLX interacting protein) and MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 39C1-39C2; 2-54 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (21286078..21310050, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (21286078..21310050, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mondo-Mlx maintains metabolic homeostasis through Activin ligand Dawdle and the Gli-similar transcription factor Sugarbabe.
Title: Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe.
these data indicate a novel role for Mio in controlling muscle structure and metabolism and may provide a molecular link between nutrient availability and muscle function.
Title: The Regulation of Muscle Structure and Metabolism by Mio/dChREBP in Drosophila.
A new function for Mio in the Drosophila brain and specifically in the insulin producing cells.
Title: Mio acts in the Drosophila brain to control nutrient storage and feeding.
these data implicate a role for Mio in controlling fat accumulation in Drosophila and suggests that it may act as a nutrient sensor in the fat body to coordinate feeding behavior with nutrient availability.
Title: Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c21289960-21289891 mobile_element_type = transposon:INE-1{}5444
Loc: c21290304-21290216 mobile_element_type = transposon:INE-1{}5445
Loc: c21296051-21295962 mobile_element_type = transposon:INE-1{}4059
Loc: c21302595-21302038 mobile_element_type = transposon:INE-1{}5450
Loc: c21307362-21306708 mobile_element_type = transposon:INE-1{}4065

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to sucrose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: mondo

Names: CG18362-PA; CG18362-PB; CG18362-PE; CG18362-PF; CG18362-PG; CG18362-PH; CG18362-PI; CG18362-PJ; CG18362-PK; CG18362-PL; CG18362-PM; Mlx interactor; Mondo-PA; Mondo-PB; Mondo-PE; Mondo-PF; Mondo-PG; Mondo-PH; Mondo-PI; Mondo-PJ; Mondo-PK; Mondo-PL; Mondo-PM; WBSCR14-related

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

21286078..21310050 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169567.2 → NP_001163038.1 mondo, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163038.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169562.2 → NP_001163033.1 mondo, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163033.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169566.2 → NP_001163037.1 mondo, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163037.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_165367.2 → NP_724326.1 mondo, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724326.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Related

FBpp0081053

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169568.2 → NP_001163039.1 mondo, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163039.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_136261.3 → NP_610105.2 mondo, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610105.2

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Related

FBpp0081052

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169564.2 → NP_001163035.1 mondo, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163035.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169563.2 → NP_001163034.1 mondo, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163034.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169565.2 → NP_001163036.1 mondo, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163036.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_165368.1 → NP_724327.1 mondo, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724327.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAC9, Q8INT6

Related

FBpp0081055, FBtr0081527

Conserved Domains (1) summary

cd00083
Location:715 → 775

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001169561.2 → NP_001163032.1 mondo, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163032.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960S1, Q9BKE5, Q9BKE6, Q9VID4

Conserved Domains (1) summary

cd00083
Location:909 → 969

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...