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    Herp Homocysteine-induced endoplasmic reticulum protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Herpprovided by FlyBase
    Official Full Name
    Homocysteine-induced endoplasmic reticulum proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031950
    Locus tag
    Dmel_CG14536
    See related
    AllianceGenome:FB:FBgn0031950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14536; dHerp; Dmel\CG14536; herp
    Summary
    Involved in endoplasmic reticulum unfolded protein response. Is expressed in several structures, including adult head; embryonic/larval garland cell; gland; gut section; and visceral mesoderm derivative. Orthologous to human HERPUD2 (HERPUD family member 2) and HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Herp in Genome Data Viewer
    Location:
    28C4-28C4; 2-28 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7796314..7800058, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7796314..7800058, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lysine ketoglutarate reductase/saccharopine dehydrogenase Neighboring gene long non-coding RNA:CR44825 Neighboring gene r2d2 Neighboring gene Cell division cycle 14 Neighboring gene LanB1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1. Kalidas S, et al. Mech Dev, 2008 May-Jun. PMID 18299191, Free PMC Article
    2. Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes. Napoli B, et al. Front Neurosci, 2019. PMID 31803000, Free PMC Article
    3. Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Kang MJ, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805114, Free PMC Article
    4. Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila. Pathak H, et al. Life Sci Alliance, 2021 Aug. PMID 34140347, Free PMC Article
    5. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Park SY, et al. Genetics, 2014 Feb. PMID 24281154, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Homocysteine-induced endoplasmic reticulum protein
    Names
    CG14536-PA
    CG14536-PC
    Herp-PA
    Herp-PC
    homocysteine-induced endoplasmic reticulum protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7796314..7800058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135307.3 → NP_609151.2  Homocysteine-induced endoplasmic reticulum protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609151.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLW9
      Conserved Domains (2) summary
      cd01790
      Location:28 → 110
      Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
      smart00213
      Location:29 → 110
      UBQ; Ubiquitin homologues

    2. NM_164772.2 → NP_723316.1  Homocysteine-induced endoplasmic reticulum protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLW9
      Related
      FBpp0079116
      Conserved Domains (2) summary
      cd01790
      Location:28 → 110
      Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
      smart00213
      Location:29 → 110
      UBQ; Ubiquitin homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZY6 Q8SZY6
    Q9VLW9 Q9VLW9

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