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    CG2017 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2017provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037391
    Locus tag
    Dmel_CG2017
    See related
    AllianceGenome:FB:FBgn0037391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 2017; Dmel\CG2017
    Summary
    Predicted to enable GTP binding activity; alpha-aminoacyl-tRNA binding activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Used to study syndromic intellectual disability. Orthologous to human GTPBP2 (GTP binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2017 in Genome Data Viewer
    Location:
    83C5-83C6; 3-47.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5858083..5862405, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1683805..1688127, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46133 Neighboring gene uncharacterized protein Neighboring gene dispatched Neighboring gene ECSIT Neighboring gene sidestep III Neighboring gene long non-coding RNA:CR45761 Neighboring gene long non-coding RNA:CR45762

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome. Salpietro V, et al. Am J Hum Genet, 2024 Jan 4. PMID 38118446, Free PMC Article
    2. Chromatin-mediated microtubule nucleation in Drosophila syncytial embryos. Hayward D, et al. Commun Integr Biol, 2014. PMID 25053984, Free PMC Article
    3. miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila. Pandey M, et al. Elife, 2021 Jun 8. PMID 34100717, Free PMC Article
    4. A screen for modifiers of RacGAP(84C) gain-of-function in the Drosophila eye revealed the LIM kinase Cdi/TESK1 as a downstream effector of Rac1 during spermatogenesis. Raymond K, et al. J Cell Sci, 2004 Jun 1. PMID 15169836
    5. New comparative genomics approach reveals a conserved health span signature across species. Antosh M, et al. Aging (Albany NY), 2011 Jun. PMID 21775776, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome.
      Title: Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-aminoacyl-tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2017-PA
    CG2017-PB
    CG2017-PC
    CG2017-PD
    CG2017-PE
    GP-1 related

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5858083..5862405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169117.2 → NP_731026.1  uncharacterized protein Dmel_CG2017, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BS2
      Related
      FBpp0078311
      Conserved Domains (4) summary
      cd04165
      Location:178 → 397
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:61 → 596
      GTPBP1; GTPase [General function prediction only]
      cd03694
      Location:411 → 497
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:508 → 595
      GTPBP_III; Domain III of the GP-1 family of GTPases

    2. NM_141346.3 → NP_649603.3  uncharacterized protein Dmel_CG2017, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649603.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960F7, Q9VNJ7
      Related
      FBpp0078310
      Conserved Domains (4) summary
      cd04165
      Location:217 → 436
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:100 → 635
      GTPBP1; GTPase [General function prediction only]
      cd03694
      Location:450 → 536
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:547 → 634
      GTPBP_III; Domain III of the GP-1 family of GTPases

    3. NM_169116.2 → NP_731025.1  uncharacterized protein Dmel_CG2017, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731025.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BS2
      Related
      FBpp0078312
      Conserved Domains (4) summary
      cd04165
      Location:178 → 397
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:61 → 596
      GTPBP1; GTPase [General function prediction only]
      cd03694
      Location:411 → 497
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:508 → 595
      GTPBP_III; Domain III of the GP-1 family of GTPases

    4. NM_169115.2 → NP_731024.1  uncharacterized protein Dmel_CG2017, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731024.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BS2
      Related
      FBpp0078313
      Conserved Domains (4) summary
      cd04165
      Location:178 → 397
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:61 → 596
      GTPBP1; GTPase [General function prediction only]
      cd03694
      Location:411 → 497
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:508 → 595
      GTPBP_III; Domain III of the GP-1 family of GTPases

    5. NM_001144540.2 → NP_001138012.1  uncharacterized protein Dmel_CG2017, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138012.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BS2
      Conserved Domains (4) summary
      cd04165
      Location:178 → 397
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:61 → 596
      GTPBP1; GTPase [General function prediction only]
      cd03694
      Location:411 → 497
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:508 → 595
      GTPBP_III; Domain III of the GP-1 family of GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BS2 Q86BS2
    Q960F7 Q960F7

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