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    Nup214 Nucleoporin 214kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup214provided by FlyBase
    Official Full Name
    Nucleoporin 214kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010660
    Locus tag
    Dmel_CG3820
    See related
    AllianceGenome:FB:FBgn0010660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CAN; CAN/Nup214; CG3820; dCAN; DCAN; Dmel\CG3820; DNup214; l(2)10444; Nup; Nup 214; nup214; NUP214
    Summary
    Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Involved in positive regulation of RNA export from nucleus and protein localization to nucleus. Located in nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nup214 in Genome Data Viewer
    Location:
    59B4-59B6; 2-101 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22918937..22924742, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18806460..18812265, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene nahoda Neighboring gene uncharacterized protein Neighboring gene Receptor expression enhancing protein A Neighboring gene uncharacterized protein Neighboring gene CCHC-type zinc finger nucleic acid binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Chou CC, et al. Nat Neurosci, 2018 Feb. PMID 29311743, Free PMC Article
    2. Analysis of Bub3 and Nup75 in the Drosophila male germline lineage. Yildirim K, et al. Cells Dev, 2023 Sep. PMID 37286104
    3. A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate. Chavan A, et al. Genes Dev, 2024 Jun 25. PMID 38866555, Free PMC Article
    4. Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology. Anderson EN, et al. Elife, 2021 May 26. PMID 34060470, Free PMC Article
    5. The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export. Roth P, et al. J Cell Biol, 2003 Nov 24. PMID 14638854, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The FG repeats of Nup153 are necessary for its function in transport, whereas the remainder of the protein maintains pore integrity.
      Title: Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport.
    2. A major function of DNup88 is to anchor DNup214 and CRM1 on the nuclear envelope and thereby attenuate NES-mediated nuclear export.
      Title: The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of RNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleoporin 214kD
    Names
    CG3820-PA
    Nup214-PA
    nucleoporin 214

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22918937..22924742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143782.3 → NP_652039.2  nucleoporin 214kD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652039.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T3K4, Q9W1X4
      Related
      FBpp0071905
      Conserved Domains (2) summary
      COG2319
      Location:31 → 233
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:38 → 86
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1X4.2 Q9W1X4

    Gene LinkOut

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