spd-2 spindle defective 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: spd-2provided by FlyBase
Official Full Name: spindle defective 2provided by FlyBase
Primary source: FLYBASE:FBgn0027500
Locus tag: Dmel_CG17286
See related: AllianceGenome:FB:FBgn0027500
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-73Ba; BcDNA:LD24702; Cep192; CEP192; CG17286; CG17286-PA; D-Spd2; D-SPD2; Dmel\CG17286; Dspd-2; DSpd-2; DSPD-2; dSpd2; Dspd2; DSpd2; Spd-2; SPD-2; spd2; Spd2; SPD2
Summary: Predicted to enable ADP-ribose diphosphatase activity. Involved in astral microtubule organization; centrosome cycle; and sperm aster formation. Located in centriole and pericentriolar material. Is expressed in several structures, including central brain primordium; ganglia; primary spermatocyte; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 73A10-73A11; 3-44 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16591207..16595014, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16584307..16588114, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spd-2 gene duplication reveals cell-type-specific pericentriolar material regulation.
Title: Spd-2 gene duplication reveals cell-type-specific pericentriolar material regulation.
Multifaceted modes of gamma-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes.
Title: Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes.
APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.
Title: APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.
These findings suggest that interactions between Spd-2, Polo and Cnn form a positive feedback loop that drives the dramatic expansion of the mitotic pericentriolar material in fly embryos.
Title: Evidence that a positive feedback loop drives centrosome maturation in fly embryos.
Spd2 is also a novel APC/C Fzr substrate. For the first time demonstrated critical importance of distinct subcellular pools of APC/C activators in the spatiotemporal control of APC/C activity.
Title: Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit.
Data indicate that interphase centrioles are closely associated with Sas-4, Spd-2, Polo kinase, Pericentrin-like protein (Dplp), Asterless (Asl), Plk4 kinase, Centrosomin (Cnn) and gamma-tubulin.
Title: Structured illumination of the interface between centriole and peri-centriolar material.
spindle defective 2 (Spd-2) functions in a very early step of the pericentriolar material recruitment pathway.
Title: Drosophila SPD-2 is an essential centriole component required for PCM recruitment and astral-microtubule nucleation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ADP-ribose diphosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in astral microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm aster formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed