U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mlt mulet [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36072, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mltprovided by FlyBase
    Official Full Name
    muletprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265512
    Locus tag
    Dmel_CG12214
    See related
    AllianceGenome:FB:FBgn0265512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12214; Dmel\CG12214; ms(2)3; ms(2)4210; ms(2)ry-3; ms(2)ry3; TBCE-like; Tbcel; TBCEL
    Summary
    Predicted to enable alpha-tubulin binding activity. Involved in positive regulation of microtubule depolymerization and sperm individualization. Located in axoneme. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; extraembryonic structure; and ganglia. Orthologous to human TBCEL (tubulin folding cofactor E like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mlt in Genome Data Viewer
    Location:
    46F3-46F3; 2-62 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10155916..10158931, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6043421..6046436, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45133 Neighboring gene KCNQ potassium channel Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46322 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hormone receptor 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tubulin-binding cofactor E-like (TBCEL), the protein product of the mulet gene, is required in the germline for the regulation of inter-flagellar microtubule dynamics during spermatid individualization. Fabrizio JJ, et al. Biol Open, 2020 Feb 26. PMID 32033965, Free PMC Article
    2. Rickettsia-like mitochondrial motility in Drosophila spermiogenesis. Bazinet C, et al. Evol Dev, 2003 Jul-Aug. PMID 12823454
    3. Mulet (mlt) encodes a tubulin-binding cofactor E-like homolog required for spermatid individualization in Drosophila melanogaster. Fabrizio JJ, et al. Fly (Austin), 2012 Oct-Dec. PMID 22885996, Free PMC Article
    4. The Drosophila homologue of tubulin-specific chaperone E-like protein is required for synchronous sperm individualization and normal male fertility. Nuwal T, et al. J Neurogenet, 2012 Sep. PMID 23121292
    5. Genetic dissection of sperm individualization in Drosophila melanogaster. Fabrizio JJ, et al. Development, 1998 May. PMID 9550716

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The work revealed that mulet (mlt), a gene required for the proper coordinated movement of the investment cones of the IC, and CG12214, which encodes the Drosophila ortholog of the tubulin-binding cofactor E-like (TBCE-like) protein,23 are allelic.
      Title: Mulet (mlt) encodes a tubulin-binding cofactor E-like homolog required for spermatid individualization in Drosophila melanogaster.
    2. Mutations affecting the Tbcel gene cause strong reduction in male, but not female, fertility and and localized in testes.
      Title: The Drosophila homologue of tubulin-specific chaperone E-like protein is required for synchronous sperm individualization and normal male fertility.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-chaperonin tubulin folding pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mulet
    Names
    CG12214-PA
    CG12214-PB
    CG12214-PC
    mlt-PA
    mlt-PB
    mlt-PC
    tubulin-specific chaperone E-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10155916..10158931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273924.1 → NP_001260853.1  mulet, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUV9, Q7K549
      Conserved Domains (4) summary
      COG4886
      Location:46 → 177
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:57 → 276
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:87 → 112
      LRR_RI; leucine-rich repeat [structural motif]
      cl00155
      Location:379 → 456
      UBQ; Ubiquitin-like proteins

    2. NM_165754.2 → NP_724901.1  mulet, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUV9, Q7K549
      Related
      FBpp0087457
      Conserved Domains (4) summary
      COG4886
      Location:46 → 177
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:57 → 276
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:87 → 112
      LRR_RI; leucine-rich repeat [structural motif]
      cl00155
      Location:379 → 456
      UBQ; Ubiquitin-like proteins

    3. NM_136718.3 → NP_610562.1  mulet, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610562.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUV9, Q7K549
      Related
      FBpp0087458
      Conserved Domains (4) summary
      COG4886
      Location:46 → 177
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:57 → 276
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:87 → 112
      LRR_RI; leucine-rich repeat [structural motif]
      cl00155
      Location:379 → 456
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K549 Q7K549

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools