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    yellow-f yellow-f [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    yellow-fprovided by FlyBase
    Official Full Name
    yellow-fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0041710
    Locus tag
    Dmel_CG18550
    See related
    AllianceGenome:FB:FBgn0041710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18550; DCDT; DI; Dmel\CG18550; yell-f; yellow f; Yellow-f; Yellow-F
    Summary
    Enables dopachrome isomerase activity and dopaminechrome tautomerase activity. Involved in indole-containing compound biosynthetic process and melanin biosynthetic process from tyrosine. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See yellow-f in Genome Data Viewer
    Location:
    87D7-87D7; 3-53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12991449..12993201, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8817171..8818923, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene polyA-binding protein interacting protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene yellow-f2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Electrochemical identification of dopachrome isomerase in Drosophila melanogaster. Li J, et al. Biochem Biophys Res Commun, 1991 Oct 31. PMID 1953745
    2. Identification of Drosophila melanogaster yellow-f and yellow-f2 proteins as dopachrome-conversion enzymes. Han Q, et al. Biochem J, 2002 Nov 15. PMID 12164780, Free PMC Article
    3. Evolution of wing pigmentation in Drosophila: Diversity, physiological regulation, and cis-regulatory evolution. Koshikawa S. Dev Growth Differ, 2020 Jun. PMID 32171022, Free PMC Article
    4. Analysis of Drosophila yellow-B cDNA reveals a new family of proteins related to the royal jelly proteins in the honeybee and to an orphan protein in an unusual bacterium Deinococcus radiodurans. Maleszka R, et al. Biochem Biophys Res Commun, 2000 Apr 21. PMID 10772900
    5. Drosophila yellow-h encodes dopaminechrome tautomerase: A new enzyme in the eumelanin biosynthetic pathway. Barek H, et al. Pigment Cell Melanoma Res, 2022 Jan. PMID 34388859

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Drosophila melanogaster yellow-f and yellow-f2 proteins as dopachrome-conversion enzymes.
      Title: Identification of Drosophila melanogaster yellow-f and yellow-f2 proteins as dopachrome-conversion enzymes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dopachrome isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dopaminechrome tautomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in developmental pigmentation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in developmental pigmentation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in indole-containing compound biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in melanin biosynthetic process from tyrosine IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in melanin biosynthetic process from tyrosine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in melanin biosynthetic process from tyrosine TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    yellow-f
    Names
    CG18550-PA
    CG18550-PB
    CG18550-PC
    Yellow-F
    dopachrome decarboxylase/tautomerase
    dopachrome isomerase
    yellow f
    yellow-f-PA
    yellow-f-PB
    yellow-f-PC
    NP_001262516.1
    NP_001262517.1
    NP_524335.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12991449..12993201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275588.1 → NP_001262517.1  yellow-f, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGZ1
      Conserved Domains (1) summary
      pfam03022
      Location:124 → 412
      MRJP; Major royal jelly protein

    2. NM_001275587.1 → NP_001262516.1  yellow-f, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262516.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHA3
      Conserved Domains (1) summary
      pfam03022
      Location:129 → 417
      MRJP; Major royal jelly protein

    3. NM_079611.2 → NP_524335.1  yellow-f, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524335.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NV9, Q9VG09
      Related
      FBpp0082191, FBtr0082723
      Conserved Domains (1) summary
      pfam03022
      Location:140 → 428
      MRJP; Major royal jelly protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGZ1 A0A0B4KGZ1
    A0A0B4KHA3 A0A0B4KHA3
    Q9VG09.1 Q9VG09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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