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    Snx27 Sorting nexin 27 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31493, updated on 9-Dec-2024

    Summary

    Official Symbol
    Snx27provided by FlyBase
    Official Full Name
    Sorting nexin 27provided by FlyBase
    Primary source
    FLYBASE:FBgn0052758
    Locus tag
    Dmel_CG32758
    See related
    AllianceGenome:FB:FBgn0052758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11465; CG3130; CG3138; CG32758; Dmel\CG32758; DmSNX27; snx27
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be active in early endosome. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Snx27 in Genome Data Viewer
    Location:
    5B2-5B3; 1-13 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5719374..5738031, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5613407..5632064, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42794 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Integrator 6 Neighboring gene Regulator of telomere elongation helicase 1

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding  
    enables phosphatidylinositol-3-phosphate binding  
    enables phosphatidylinositol-3-phosphate binding  
    Process Evidence Code Pubs
    involved_in endocytic recycling  
    involved_in intracellular protein transport  
    involved_in intracellular protein transport  
    involved_in intracellular protein transport  
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in early endosome  
    located_in early endosome  

    General protein information

    Preferred Names
    sorting nexin 27
    Names
    CG32758-PA
    CG32758-PC
    CG32758-PD
    Snx27-PA
    Snx27-PC
    Snx27-PD
    NP_001259258.1
    NP_001284906.1
    NP_727023.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5719374..5738031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297977.1 → NP_001284906.1  sorting nexin 27, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JIH1
      Conserved Domains (4) summary
      cd06886
      Location:64 → 169
      PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
      cd00992
      Location:9 → 37
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13338
      Location:327 → 427
      FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
      cd01777
      Location:176 → 267
      FERM_F1_SNX27; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in sorting nexin protein 27 (SNX27)
    2. NM_001272329.2 → NP_001259258.1  sorting nexin 27, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259258.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD98
      Conserved Domains (4) summary
      cd06886
      Location:77 → 182
      PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
      cd00992
      Location:22 → 50
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13338
      Location:340 → 440
      FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
      cl00155
      Location:190 → 275
      UBQ; Ubiquitin-like proteins
    3. NM_167045.3 → NP_727023.1  sorting nexin 27, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W486
      Related
      FBpp0070808
      Conserved Domains (4) summary
      cd06886
      Location:165 → 270
      PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27
      cd00992
      Location:46 → 138
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13338
      Location:428 → 528
      FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27
      cl00155
      Location:278 → 363
      UBQ; Ubiquitin-like proteins
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