sw short wing [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: swprovided by FlyBase
Official Full Name: short wingprovided by FlyBase
Primary source: FLYBASE:FBgn0003654
Locus tag: Dmel_CG18000
See related: AllianceGenome:FB:FBgn0003654
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 17-234; cDIC; Cdic; Cdic2b; CG18000; dic; Dic; DIC; Dic19B; Dic19C; Dmel\CG18000; IC; IC74; l(1)19Bb; sw CES
Summary: Enables dynactin binding activity and dynein light chain binding activity. Involved in several processes, including centrosome localization; protein localization to kinetochore; and sperm individualization. Part of cytoplasmic dynein complex. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19C1-19C1; 1-64 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (20227961..20236382, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (20099035..20107456, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LC8 binding promotes IC self-association of helix 1 from each of two IC chains, whereas LC7 binding reverses self-association by incorporating the same residues into two symmetrical, but distant, helices of the LC7-IC complex
Title: Light chain-dependent self-association of dynein intermediate chain.
Crystal structures of Drosophila melanogaster LC7 in the apo form and in complex with a segment of the disordered N-terminal domain of dynein intermediate chain (IC) provide the first definitive identification of the IC sequence recognized by LC7.
Title: The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly.
The N-terminal domain of cytoplasmic dynein intermediate chain (residues 1-289, IC74) is highly disordered, but upon binding to dynein light chain LC8 it gains helical structure and becomes more condensed.
Title: The intermediate chain of cytoplasmic dynein is partially disordered and gains structure upon binding to light-chain LC8.
Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74
Title: Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm0499 (e-PCR)
- UniSTS:56508

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables dynactin binding	IPI Inferred from Physical Interaction more info	PubMed
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein heavy chain binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye photoreceptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IDA Inferred from Direct Assay more info	PubMed
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: short wing

Names: CG18000-PA; CG18000-PB; CG18000-PC; CG18000-PD; CG18000-PE; CG18000-PF; CG18000-PG; CG18000-PH; CG18000-PI; CG18000-PJ; CG18000-PK; CG18000-PL; CG18000-PM; CG18000-PN; CG18000-PO; cytoplasmic dynein; cytoplasmic dynein intermediate chain; cytoplasmic dynein intermediate polypeptide chain; dynein; dynein IC; dynein intermediate chain; dynein intermediate-chain; sw-PA; sw-PB; sw-PC; sw-PD; sw-PE; sw-PF; sw-PG; sw-PH; sw-PI; sw-PJ; sw-PK; sw-PL; sw-PM; sw-PN; sw-PO; swallow

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

20227961..20236382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057730.5 → NP_477078.1 short wing, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477078.1

Status: REVIEWED

UniProtKB/TrEMBL

E6PBX0, E8NH86

Related

FBpp0088423

Conserved Domains (3) summary

sd00039
Location:295 → 344

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:295 → 611

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057722.4 → NP_477070.1 short wing, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477070.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH86

Related

FBpp0088425

Conserved Domains (3) summary

sd00039
Location:289 → 338

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:289 → 605

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001298558.1 → NP_001285487.1 short wing, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285487.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH86, X2JLF7

Conserved Domains (3) summary

sd00039
Location:296 → 345

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:296 → 612

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057728.4 → NP_477076.1 short wing, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477076.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH86

Related

FBpp0088421

Conserved Domains (5) summary

COG2319
Location:307 → 606

WD40; WD40 repeat [General function prediction only]

COG2811
Location:191 → 261

NtpH; Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

sd00039
Location:279 → 328

7WD40; WD40 repeat [structural motif]

cl02567
Location:279 → 595

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057729.4 → NP_477077.1 short wing, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477077.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH86

Related

FBpp0088420

Conserved Domains (3) summary

sd00039
Location:280 → 329

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:280 → 596

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001298557.1 → NP_001285486.1 short wing, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285486.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH77, E8NH86

Conserved Domains (3) summary

sd00039
Location:287 → 336

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:287 → 603

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057721.4 → NP_477069.1 short wing, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477069.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4T4, E8NH86

Related

FBpp0088422

Conserved Domains (3) summary

sd00039
Location:296 → 345

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:296 → 612

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057731.4 → NP_477079.1 short wing, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477079.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH86

Related

FBpp0088424

Conserved Domains (3) summary

sd00039
Location:303 → 352

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:303 → 619

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_206799.2 → NP_996522.1 short wing, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996522.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4T4, E8NH86

Conserved Domains (3) summary

sd00039
Location:296 → 345

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:296 → 612

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057724.4 → NP_477072.1 short wing, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477072.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH86

Related

FBpp0088427

Conserved Domains (3) summary

sd00039
Location:280 → 329

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:280 → 596

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057723.4 → NP_477071.1 short wing, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477071.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH86

Related

FBpp0088426

Conserved Domains (3) summary

sd00039
Location:288 → 337

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:288 → 604

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057726.4 → NP_477074.1 short wing, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477074.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH77, E8NH86

Related

FBpp0088419

Conserved Domains (3) summary

sd00039
Location:287 → 336

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:287 → 603

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057725.4 → NP_477073.1 short wing, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477073.1

Status: REVIEWED

UniProtKB/TrEMBL

E8NH86, F2FB48

Related

FBpp0088429

Conserved Domains (3) summary

sd00039
Location:306 → 355

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:306 → 622

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_057727.5 → NP_477075.2 short wing, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477075.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O96508, O96510, O96511, O96512, O96513, O96514, O96515, O96516, Q24246, Q5U0Z1, Q86BQ5, Q9NG49, Q9TZR7, Q9TZR8, Q9TZR9, Q9TZS0, Q9VR78

UniProtKB/TrEMBL

E8NH86

Related

FBpp0088428

Conserved Domains (3) summary

sd00039
Location:316 → 365

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:316 → 632

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_206798.2 → NP_996521.1 short wing, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996521.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4T4, E8NH86

Conserved Domains (3) summary

sd00039
Location:296 → 345

7WD40; WD40 repeat [structural motif]

pfam11540
Location:107 → 135

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:296 → 612

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...