tap target of Poxn [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tapprovided by FlyBase
Official Full Name: target of Poxnprovided by FlyBase
Primary source: FLYBASE:FBgn0015550
Locus tag: Dmel_CG7659
See related: AllianceGenome:FB:FBgn0015550
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bHLHc9; bps; CG7659; Dmel\CG7659; l(3)01658; Tap; TAP
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in axon guidance; mushroom body development; and negative regulation of axon extension involved in axon guidance. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; ganglia; head epidermis primordium; presumptive embryonic/larval system; and somatic precursor cell. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG1 (neurogenin 1); NEUROG2 (neurogenin 2); and NEUROG3 (neurogenin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (17359682..17361811)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (17352782..17354911)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

TAP/p32, similar to NAP-1, NLP, and Nph, facilitates nucleosome assembly in vitro and is therefore a histone chaperone
Title: Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	TAS Traceable Author Statement more info	PubMed