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    CG4041 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31422, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4041provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029736
    Locus tag
    Dmel_CG4041
    See related
    AllianceGenome:FB:FBgn0029736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4041
    Summary
    Predicted to enable GTPase activator activity. Involved in Golgi organization. Is expressed in embryonic/larval garland cell; garland cell primordium; gonad; and organism. Human ortholog(s) of this gene implicated in infantile hypotonia with psychomotor retardation and characteristic facies-3. Orthologous to human TBCK (TBC1 domain containing kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4041 in Genome Data Viewer
    Location:
    4D5-4D6; 1-9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4915280..4918447, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4809313..4812480, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hairpin RNA:CR46342 Neighboring gene Heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanisms of HP1-mediated gene silencing in Drosophila. Danzer JR, et al. Development, 2004 Aug. PMID 15215206
    2. Classification of nonenzymatic homologues of protein kinases. Anamika K, et al. Comp Funct Genomics, 2009. PMID 19809514, Free PMC Article
    3. ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. Zacharogianni M, et al. EMBO J, 2011 Aug 16. PMID 21847093, Free PMC Article
    4. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    5. A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect. Shaukat Z, et al. PLoS One, 2012. PMID 23077619, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4041-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4915280..4918447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_131969.5 → NP_572197.4  uncharacterized protein Dmel_CG4041 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572197.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNA4, Q9W4F8
      Conserved Domains (3) summary
      smart00164
      Location:432 → 634
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01525
      Location:706 → 810
      RHOD_Kc; Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site ...
      cl21453
      Location:45 → 272
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4F8 Q9W4F8

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